The domain within your query sequence starts at position 2182 and ends at position 2320; the E-value for the RPT_5 domain shown below is 2.93e-5.

SSRTPQAPTPANLVVGPRSAHGTAPVNIAGSRTPAGLAPTNLSSSRMAPALSGANLTSPR
VPLSAYDRVSGRTSPLMLDRARSRTPPSAPSQSRMTSERERAPSPASRMVQASSQSLLPP
AQDRPRSPVPSAFSDQSRS

This is a significant internal repeat in the query protein sequence, as detected by the Prospero program.