The domain within your query sequence starts at position 918 and ends at position 1095; the E-value for the RhoGAP domain shown below is 6.83e-65.



GTPase-activator protein for Rho-like GTPases
SMART accession number:SM00324
Description: GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases. etter domain limits and outliers.
Interpro abstract (IPR000198):

Members of the Rho family of small G proteins transduce signals from plasma-membrane receptors and control cell adhesion, motility and shape by actin cytoskeleton formation. Like all other GTPases, Rho proteins act as molecular switches, with an active GTP-bound form and an inactive GDP-bound form. The active conformation is promoted by guanine-nucleotide exchange factors, and the inactive state by GTPase-activating proteins (GAPs) which stimulate the intrinsic GTPase activity of small G proteins. This entry is a Rho/Rac/Cdc42-like GAP domain, that is found in a wide variety of large, multi-functional proteins [ (PUBMED:9009196) ]. A number of structure are known for this family [ (PUBMED:9009196) (PUBMED:8962058) (PUBMED:9262406) ]. The domain is composed of seven alpha helices. This domain is also known as the breakpoint cluster region-homology (BH) domain.

GO process:signal transduction (GO:0007165)
Family alignment:
View or

There are 47093 RhoGAP domains in 46979 proteins in SMART's nrdb database.

Click on the following links for more information.