 SARASmad anchor for receptor activation (SARA) | |
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| SMART ACC: | SM001422 |
| Description: | Smad proteins mediate transforming growth factor-beta (TGF-beta) signaling from the transmembrane serine-threonine receptor kinases to the nucleus PMID:10615055. SARA recruits Smad2 to the TGF-beta receptors for phosphorylation PMID:10615055. |
| InterPro ACC: | IPR024608 |
| InterPro abstract: | This entry represents the Smad-binding domain (SBD) of SARA, which is also known as Zinc finger FYVE domain-containing protein 9. This domain consists of a rigid coil, an α-helix, and a β-strand, and interacts with Smad2 [ PUBMED:10615055 ]. It is found C-terminal to the FYVE zinc finger domain ( IPR000306 … expand |
| Family alignment: | View the Family alignment or the Alignment consensus sequence |
| There are 0 SARA domains in 0 proteins in SMART's NRDB database. | |
Predicted cellular role
| Cellular role: | Signalling |
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Relevant references for this domain
Primary literature for the SARA domain is listed below.
KEGG pathways involving proteins which contain this domain
This information is based on the mapping of SMART genomic protein database to KEGG orthologous groups. Percentages are related to the number of proteins containing a SARA domain which could be assigned to a KEGG orthologous group, and not all proteins containing SARA domains. Please note that proteins can be included in multiple pathways, ie. the numbers below will not add to 100%.