The domain within your query sequence starts at position 161 and ends at position 246; the E-value for the d1sig__ domain shown below is 1e-2.

DDDDDDHDDHEDNDKMNDSEGMDPERLKAFNMFVRLFVDENLDRMVPISKQPKEKIQAII
ESCSRQFPEFQERARKRIRTYLKSCR

This is a SCOP domain - please see the SCOP entry of d1sig__ for further annotation