The domain within your query sequence starts at position 412 and ends at position 491; the E-value for the S_TK_X domain shown below is 5.3e-9.

RSLDWQMVFLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDSDQELYRNFPLTI
SERWQQEVAETVFDTINAET

S_TK_X

Extension to Ser/Thr-type protein kinases

• SMART accession number: SM00133
• Description: -
• Interpro abstract (IPR000961):

  Protein phosphorylation, which plays a key role in most cellular activities, is a reversible process mediated by protein kinases and phosphoprotein phosphatases. Protein kinases catalyse the transfer of the gamma phosphate from nucleotide triphosphates (often ATP) to one or more amino acid residues in a protein substrate side chain, resulting in a conformational change affecting protein function. Phosphoprotein phosphatases catalyse the reverse process. Protein kinases fall into three broad classes, characterised with respect to substrate specificity [ (PUBMED:3291115) ]:

  • Serine/threonine-protein kinases
  • Tyrosine-protein kinases
  • Dual specificity protein kinases (e.g. MEK - phosphorylates both Thr and Tyr on target proteins)

  Protein kinase function is evolutionarily conserved from Escherichia coli to human [ (PUBMED:12471243) ]. Protein kinases play a role in a multitude of cellular processes, including division, proliferation, apoptosis, and differentiation [ (PUBMED:12368087) ]. Phosphorylation usually results in a functional change of the target protein by changing enzyme activity, cellular location, or association with other proteins. The catalytic subunits of protein kinases are highly conserved, and several structures have been solved [ (PUBMED:15078142) ], leading to large screens to develop kinase-specific inhibitors for the treatments of a number of diseases [ (PUBMED:15320712) ].

  The AGC (cAMP-dependent, cGMP-dependent and protein kinase C) protein kinase family embraces a collection of protein kinases that display a high degree of sequence similarity within their respective kinase domains. AGC kinase proteins are characterised by three conserved phosphorylation sites that critically regulate their function. The first one is located in an activation loop in the centre of the kinase domain. The two other phosphorylation sites are located outside the kinase domain in a conserved region on its C-terminal side, the AGC-kinase C-terminal domain. These sites serves as phosphorylation-regulated switches to control both intra- and inter-molecular interactions. Without these priming phosphorylations, the kinases are catalytically inactive [ (PUBMED:12495431) (PUBMED:11709088) (PUBMED:15209375) ].

  Several structures of the AGC-kinase C-terminal domain have been solved. The first phosphorylation site is located in a turn motif, the second one at the end of the domain in an hydrophobic pocket. In PKB the phosphorylated hydrophobic motif engages a hydrophobic groove within the N-lobe of the kinase domain which orders alpha helices close to the active site [ (PUBMED:12434148) ].

• GO process: protein phosphorylation (GO:0006468)
• GO function: protein serine/threonine kinase activity (GO:0004674), ATP binding (GO:0005524)

There are 38412 S_TK_X domains in 38361 proteins in SMART's nrdb database.

Disease (disease genes where sequence variants are found in this domain)

SwissProt sequences and OMIM curated human diseases associated with missense mutations within the S_TK_X domain.

Protein	Disease
Rhodopsin kinase (Q15835) (SMART)	OMIM:180381: Oguchi disease-2 OMIM:258100:
Protein kinase C gamma type (P05129) (SMART)	OMIM:176980: PROTEIN KINASE C, GAMMA; PRKCG

Metabolism (metabolic pathways involving proteins which contain this domain)

% proteins involved	KEGG pathway ID	Description
6.60	map04010	MAPK signaling pathway
4.74	map04720	Long-term potentiation
4.74	map04910	Insulin signaling pathway
4.64	map04530	Tight junction
4.49	map04914	Progesterone-mediated oocyte maturation
4.20	map04310	Wnt signaling pathway
4.20	map04540	Gap junction
3.42	map04510	Focal adhesion
3.42	map04012	ErbB signaling pathway
3.37	map04020	Calcium signaling pathway
3.37	map04916	Melanogenesis
3.37	map04150	mTOR signaling pathway
3.13	map04210	Apoptosis
2.78	map04740	Olfactory transduction
2.59	map04370	VEGF signaling pathway
2.59	map05214	Glioma
2.59	map05223	Non-small cell lung cancer
2.25	map04670	Leukocyte transendothelial migration
2.25	map04730	Long-term depression
2.00	map05221	Acute myeloid leukemia
1.95	map04742	Taste transduction
1.95	map04912	GnRH signaling pathway
1.95	map04340	Hedgehog signaling pathway
1.66	map04350	TGF-beta signaling pathway
1.42	map04070	Phosphatidylinositol signaling system
1.42	map04650	Natural killer cell mediated cytotoxicity
1.17	map05222	Small cell lung cancer
1.17	map05213	Endometrial cancer
1.17	map04662	B cell receptor signaling pathway
1.17	map05212	Pancreatic cancer
1.17	map04630	Jak-STAT signaling pathway
1.17	map05220	Chronic myeloid leukemia
1.17	map04920	Adipocytokine signaling pathway
1.17	map04664	Fc epsilon RI signaling pathway
1.17	map05210	Colorectal cancer
1.17	map04620	Toll-like receptor signaling pathway
1.17	map05215	Prostate cancer
1.17	map04660	T cell receptor signaling pathway
1.17	map05211	Renal cell carcinoma
1.17	map05218	Melanoma
0.83	map04810	Regulation of actin cytoskeleton
0.83	map04360	Axon guidance
0.29	map00632	Benzoate degradation via CoA ligation
0.29	map00562	Inositol phosphate metabolism
0.24	map04111	Cell cycle - yeast

This information is based on mapping of SMART genomic protein database to KEGG orthologous groups. Percentage points are related to the number of proteins with S_TK_X domain which could be assigned to a KEGG orthologous group, and not all proteins containing S_TK_X domain. Please note that proteins can be included in multiple pathways, ie. the numbers above will not always add up to 100%.

Structure (3D structures containing this domain)

3D Structures of S_TK_X domains in PDB

PDB code	Title
1apm	2.0 ANGSTROM REFINED CRYSTAL STRUCTURE OF THE CATALYTIC SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE COMPLEXED WITH A PEPTIDE INHIBITOR AND DETERGENT
1atp	2.2 ANGSTROM REFINED CRYSTAL STRUCTURE OF THE CATALYTIC SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE COMPLEXED WITH MNATP AND A PEPTIDE INHIBITOR
1bkx	A BINARY COMPLEX OF THE CATALYTIC SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE AND ADENOSINE FURTHER DEFINES CONFORMATIONAL FLEXIBILITY
1bx6	CRYSTAL STRUCTURE OF THE POTENT NATURAL PRODUCT INHIBITOR BALANOL IN COMPLEX WITH THE CATALYTIC SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE
1cdk	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT (E.C.2.7.1.37) (PROTEIN KINASE A) COMPLEXED WITH PROTEIN KINASE INHIBITOR PEPTIDE FRAGMENT 5-24 (PKI(5-24) ISOELECTRIC VARIANT CA) AND MN2+ ADENYLYL IMIDODIPHOSPHATE (MNAMP-PNP) AT PH 5.6 AND 7C AND 4C
1cmk	CRYSTAL STRUCTURES OF THE MYRISTYLATED CATALYTIC SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE REVEAL OPEN AND CLOSED CONFORMATIONS
1ctp	STRUCTURE OF THE MAMMALIAN CATALYTIC SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE AND AN INHIBITOR PEPTIDE DISPLAYS AN OPEN CONFORMATION
1fmo	CRYSTAL STRUCTURE OF A POLYHISTIDINE-TAGGED RECOMBINANT CATALYTIC SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE COMPLEXED WITH THE PEPTIDE INHIBITOR PKI(5-24) AND ADENOSINE
1fot	STRUCTURE OF THE UNLIGANDED CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT FROM SACCHAROMYCES CEREVISIAE
1gzk	Molecular mechanism for the regulation of protein kinase B/Akt by hydrophobic motif phosphorylation
1gzn	Structure of PKB kinase domain
1gzo	Structure of protein kinase B unphosphorylated
1j3h	Crystal structure of apoenzyme cAMP-dependent protein kinase catalytic subunit
1jbp	Crystal Structure of the Catalytic Subunit of cAMP-dependent Protein Kinase Complexed with a Substrate Peptide, ADP and Detergent
1jlu	Crystal Structure of the Catalytic Subunit of cAMP-dependent Protein Kinase Complexed with a Phosphorylated Substrate Peptide and Detergent
1l3r	Crystal Structure of a Transition State Mimic of the Catalytic Subunit of cAMP-dependent Protein Kinase
1mrv	crystal structure of an inactive Akt2 kinase domain
1mry	crystal structure of an inactive akt2 kinase domain
1o6k	Structure of activated form of PKB kinase domain S474D with GSK3 peptide and AMP-PNP
1o6l	Crystal structure of an activated Akt/protein kinase B (PKB-PIF chimera) ternary complex with AMP-PNP and GSK3 peptide
1omw	Crystal Structure of the complex between G Protein-Coupled Receptor Kinase 2 and Heterotrimeric G Protein beta 1 and gamma 2 subunits
1q24	PKA double mutant model of PKB in complex with MgATP
1q61	PKA triple mutant model of PKB
1q62	PKA double mutant model of PKB
1q8t	The Catalytic Subunit of cAMP-dependent Protein Kinase (PKA) in Complex with Rho-kinase Inhibitor Y-27632
1q8u	The Catalytic Subunit of cAMP-dependent Protein Kinase in Complex with Rho-kinase Inhibitor H-1152P
1q8w	The Catalytic Subunit of cAMP-dependent Protein Kinase in Complex with Rho-kinase Inhibitor Fasudil (HA-1077)
1rdq	Hydrolysis of ATP in the crystal of Y204A mutant of cAMP-dependent protein kinase
1re8	Crystal structure of cAMP-dependent protein kinase complexed with balanol analog 2
1rej	Crystal structure of cAMP-dependent protein kinase complexed with balanol analog 1
1rek	Crystal structure of cAMP-dependent protein kinase complexed with balanol analog 8
1smh	Protein kinase A variant complex with completely ordered N-terminal helix
1stc	CAMP-DEPENDENT PROTEIN KINASE, ALPHA-CATALYTIC SUBUNIT IN COMPLEX WITH STAUROSPORINE
1sve	Crystal Structure of Protein Kinase A in Complex with Azepane Derivative 1
1svg	Crystal Structure of Protein Kinase A in Complex with Azepane Derivative 4
1svh	Crystal Structure of Protein Kinase A in Complex with Azepane Derivative 8
1syk	Crystal structure of E230Q mutant of cAMP-dependent protein kinase reveals unexpected apoenzyme conformation
1szm	DUAL BINDING MODE OF BISINDOLYLMALEIMIDE 2 TO PROTEIN KINASE A (PKA)
1veb	Crystal Structure of Protein Kinase A in Complex with Azepane Derivative 5
1xh4	Crystal Structures of Protein Kinase B Selective Inhibitors in Complex with Protein Kinase A and Mutants
1xh5	Crystal Structures of Protein Kinase B Selective Inhibitors in Complex with Protein Kinase A and Mutants
1xh6	Crystal Structures of Protein Kinase B Selective Inhibitors in Complex with Protein Kinase A and Mutants
1xh7	Crystal Structures of Protein Kinase B Selective Inhibitors in Complex with Protein Kinase A and Mutants
1xh8	Crystal Structures of Protein Kinase B Selective Inhibitors in Complex with Protein Kinase A and Mutants
1xh9	Crystal Structures of Protein Kinase B Selective Inhibitors in Complex with Protein Kinase A and Mutants
1xha	Crystal Structures of Protein Kinase B Selective Inhibitors in Complex with Protein Kinase A and Mutants
1xjd	Crystal Structure of PKC-theta complexed with Staurosporine at 2A resolution
1ydr	STRUCTURE OF CAMP-DEPENDENT PROTEIN KINASE, ALPHA-CATALYTIC SUBUNIT IN COMPLEX WITH H7 PROTEIN KINASE INHIBITOR 1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE
1yds	STRUCTURE OF CAMP-DEPENDENT PROTEIN KINASE, ALPHA-CATALYTIC SUBUNIT IN COMPLEX WITH H8 PROTEIN KINASE INHIBITOR [N-(2-METHYLAMINO)ETHYL]-5-ISOQUINOLINESULFONAMIDE
1ydt	STRUCTURE OF CAMP-DEPENDENT PROTEIN KINASE, ALPHA-CATALYTIC SUBUNIT IN COMPLEX WITH H89 PROTEIN KINASE INHIBITOR N-[2-(4-BROMOCINNAMYLAMINO)ETHYL]-5-ISOQUINOLINE
1ym7	G Protein-Coupled Receptor Kinase 2 (GRK2)
1zrz	Crystal Structure of the Catalytic Domain of Atypical Protein Kinase C-iota
2acx	Crystal Structure of G protein coupled receptor kinase 6 bound to AMPPNP
2bcj	Crystal Structure of G Protein-Coupled Receptor Kinase 2 in Complex with Galpha-q and Gbetagamma Subunits
2c1a	Structure of cAMP-dependent protein kinase complexed with Isoquinoline-5-sulfonic acid (2-(2-(4-chlorobenzyloxy)ethylamino) ethyl)amide
2c1b	Structure of cAMP-dependent protein kinase complexed with (4R,2S)-5'-( 4-(4-Chlorobenzyloxy)pyrrolidin-2-ylmethanesulfonyl)isoquinoline
2cpk	CRYSTAL STRUCTURE OF THE CATALYTIC SUBUNIT OF CYCLIC ADENOSINE MONOPHOSPHATE-DEPENDENT PROTEIN KINASE
2erz	Crystal Structure of c-AMP Dependent Kinase (PKA) bound to hydroxyfasudil
2esm	Crystal Structure of ROCK 1 bound to fasudil
2etk	Crystal Structure of ROCK 1 bound to hydroxyfasudil
2etr	Crystal Structure of ROCK I bound to Y-27632
2f2u	crystal structure of the Rho-kinase kinase domain
2f7e	PKA complexed with (S)-2-(1H-Indol-3-yl)-1-(5-isoquinolin-6-yl-pyridin-3-yloxymethyl-etylamine
2f7x	Protein Kinase A bound to (S)-2-(1H-Indol-3-yl)-1-[5-((E)-2-pyridin-4-yl-vinyl)-pyridin-3-yloxymethyl]-ethylamine
2f7z	Protein Kinase A bound to (R)-1-(1H-Indol-3-ylmethyl)-2-(2-pyridin-4-yl-[1,7]naphtyridin-5-yloxy)-ehylamine
2gfc	cAMP-dependent protein kinase PKA catalytic subunit with PKI-5-24
2gnf	Protein kinase A fivefold mutant model of Rho-kinase with Y-27632
2gng	Protein kinase A fivefold mutant model of Rho-kinase
2gnh	PKA five fold mutant model of Rho-kinase with H1152P
2gni	PKA fivefold mutant model of Rho-kinase with inhibitor Fasudil (HA1077)
2gnj	PKA three fold mutant model of Rho-kinase with Y-27632
2gnl	PKA threefold mutant model of Rho-kinase with inhibitor H-1152P
2gu8	Discovery of 2-Pyrimidyl-5-Amidothiophenes as Novel and Potent Inhibitors for AKT: Synthesis and SAR Studies
2h9v	Structural basis for induced-fit binding of Rho-kinase to the inhibitor Y27632
2i0e	Structure of catalytic domain of human protein kinase C beta II complexed with a bisindolylmaleimide inhibitor
2jdo	STRUCTURE OF PKB-BETA (AKT2) COMPLEXED WITH ISOQUINOLINE-5-SULFONIC ACID (2-(2-(4-CHLOROBENZYLOXY) ETHYLAMINO)ETHYL)AMIDE
2jdr	STRUCTURE OF PKB-BETA (AKT2) COMPLEXED WITH THE INHIBITOR A-443654
2jds	Structure of cAMP-dependent protein kinase complexed with A-443654
2jdt	Structure of PKA-PKB chimera complexed with ISOQUINOLINE-5-SULFONIC ACID (2-(2-(4-CHLOROBENZYLOXY) ETHYLAMINO)ETHYL)AMIDE
2jdv	Structure of PKA-PKB chimera complexed with A-443654
2jed	The crystal structure of the kinase domain of the protein kinase C theta in complex with NVP-XAA228 at 2.32A resolution.
2oh0	Crystal structure of Protein Kinase A in complex with Pyridine-Pyrazolopyridine Based Inhibitors
2ojf	Crystal structure of Protein Kinase A in complex with Pyridine-Pyrazolopyridine based inhibitors
2qcs	A complex structure between the Catalytic and Regulatory subunit of Protein Kinase A that represents the inhibited state
2qur	Crystal Structure of F327A/K285P Mutant of cAMP-dependent Protein Kinase
2qvs	Crystal Structure of Type IIa Holoenzyme of cAMP-dependent Protein Kinase
2r5t	Crystal Structure of Inactive Serum and Glucocorticoid- Regulated Kinase 1 in Complex with AMP-PNP
2uvx	Structure of PKA-PKB chimera complexed with 7-azaindole
2uvy	Structure of PKA-PKB chimera complexed with methyl-(4-(9H-purin-6-yl)- benzyl)-amine
2uvz	Structure of PKA-PKB chimera complexed with C-Phenyl-C-(4-(9H-purin-6- yl)-phenyl)-methylamine
2uw0	Structure of PKA-PKB chimera complexed with 6-(4-(4-(4-Chloro-phenyl) -piperidin-4-yl)-phenyl)-9H-purine
2uw3	Structure of PKA-PKB chimera complexed with 5-methyl-4-phenyl-1H- pyrazole
2uw4	Structure of PKA-PKB chimera complexed with 2-(4-(5-methyl-1H-pyrazol- 4-yl)-phenyl)-ethylamine
2uw5	Structure of PKA-PKB chimera complexed with (R)-2-(4-chloro-phenyl)- 2-(4-1H-pyrazol-4-yl)-phenyl)-ethylamine
2uw6	Structure of PKA-PKB chimera complexed with (S)-2-(4-chloro-phenyl)- 2-(4-1H-pyrazol-4-yl)-phenyl)-ethylamine
2uw7	Structure of PKA-PKB chimera complexed with 4-(4-chloro-phenyl)-4-(4- (1H-pyrazol-4-yl)-phenyl)-piperidine
2uw8	Structure of PKA-PKB chimera complexed with 2-(4-chloro-phenyl)-2- phenyl-ethylamine
2uw9	STRUCTURE OF PKB-BETA (AKT2) COMPLEXED WITH 4-(4-chloro-phenyl)-4-(4-( 1H-pyrazol-4-yl)-phenyl)-piperidine
2uzt	PKA structures of AKT, indazole-pyridine inhibitors
2uzu	PKA structures of indazole-pyridine series of AKT inhibitors
2uzv	PKA structures of indazole-pyridine series of AKT inhibitors
2uzw	PKA structures of indazole-pyridine series of AKT inhibitors
2v55	Mechanism of multi-site phosphorylation from a ROCK-I:RhoE complex structure
2vd5	Structure of Human Myotonic Dystrophy Protein Kinase in Complex with the Bisindoylmaleide inhibitor BIM VIII
2vnw	Structure of PKA-PKB chimera complexed with (1-(9H-Purin-6-yl) piperidin-4-yl)methanamine
2vny	Structure of PKA-PKB chimera complexed with (1-(9H-Purin-6-yl) piperidin-4-yl)amine
2vo0	Structure of PKA-PKB chimera complexed with C-(4-(4-Chlorophenyl)-1-( 7H-pyrrolo(2,3-d)pyrimidin-4-yl)piperidin-4-yl)methylamine
2vo3	Structure of PKA-PKB chimera complexed with C-(4-(4-Chlorobenzyl)-1-( 7H-pyrrolo(2,3-d)pyrimidin-4-yl)piperidin-4-yl)methylamine
2vo6	Structure of PKA-PKB chimera complexed with 4-(4-Chlorobenzyl)-1-(7H- pyrrolo(2,3-d)pyrimidin-4-yl)piperidin-4-ylamine
2vo7	Structure of PKA complexed with 4-(4-Chlorobenzyl)-1-(7H-pyrrolo(2,3- d)pyrimidin-4-yl)piperidin-4-ylamine
2x39	Structure of 4-Amino-N-(4-chlorobenzyl)-1-(7H-pyrrolo(2,3-d)pyrimidin- 4-yl)piperidine-4-carboxamide bound to PKB
2xh5	Structure of 4-(4-tert-Butylbenzyl)-1-(7H-pyrrolo(2,3-d)pyrimidin-4- yl)piperidin-4-amine bound to PKB
2z7q	Crystal structure of the N-terminal kinase domain of human RSK-1 bound to AMP-PCP
2z7r	Crystal Structure of the N-terminal Kinase Domain of Human RSK1 bound to Staurosporine
2z7s	Crystal Structure of the N-terminal Kinase Domain of Human RSK1 bound to Purvalnol A
3a60	Crystal structure of unphosphorylated p70S6K1 (Form I)
3a61	Crystal structure of unphosphorylated p70S6K1 (Form II)
3a62	Crystal structure of phosphorylated p70S6K1
3a8w	Crystal Structure of PKCiota kinase domain
3a8x	Crystal Structure of PKCiota kinase domain
3ag9	Complex of PKA with the bisubstrate protein kinase inhibitor ARC-1012
3agl	Complex of PKA with the bisubstrate protein kinase inhibitor ARC-1039
3agm	Complex of PKA with the bisubstrate protein kinase inhibitor ARC-670
3ama	Protein kinase A sixfold mutant model of Aurora B with inhibitor JNJ-7706621
3amb	Protein kinase A sixfold mutant model of Aurora B with inhibitor VX-680
3bwj	Complex of PKA with the bisubstrate protein kinase inhibitor lead compound Arc-1034
3c4w	Crystal Structure of G protein coupled receptor kinase 1 bound to ATP and magnesium chloride at 2.7A
3c4x	Crystal Structure of G protein coupled receptor kinase 1 bound to ATP and magnesium chloride at 2.9A
3c4y	Crystal Structure of Apo form of G protein coupled receptor kinase 1 at 7.51A
3c4z	Crystal structure of G protein coupled receptor kinase 1 bound to ADP and magnesium chloride at 1.84A
3c50	Crystal Structure of G protein coupled receptor kinase 1 bound to ADP and magnesium chloride at 2.6A
3c51	Crystal structure of G protein coupled receptor kinase 1 bound to ADP and magnesium chloride at 3.55A
3cik	Human GRK2 in Complex with Gbetagamma subunits
3cqu	Crystal Structure of Akt-1 complexed with substrate peptide and inhibitor
3cqw	Crystal Structure of Akt-1 complexed with substrate peptide and inhibitor
3d0e	Crystal structure of human Akt2 in complex with GSK690693
3d9v	CRYSTAL STRUCTURE OF ROCK I BOUND TO H-1152P A DI-METHYLATED VARIANT OF FASUDIL
3dnd	cAMP-dependent protein kinase PKA catalytic subunit with PKI-5-24
3dne	cAMP-dependent protein kinase PKA catalytic subunit with PKI-5-24
3e87	Crystal structures of the kinase domain of AKT2 in complex with ATP-competitive inhibitors
3e88	Crystal structures of the kinase domain of AKT2 in complex with ATP-competitive inhibitors
3e8c	Crystal structures of the kinase domain of PKA in complex with ATP-competitive inhibitors
3e8d	Crystal structures of the kinase domain of AKT2 in complex with ATP-competitive inhibitors
3e8e	Crystal structures of the kinase domain of PKA in complex with ATP-competitive inhibitors
3fhi	Crystal structure of a complex between the catalytic and regulatory (RI{alpha}) subunits of PKA
3fjq	Crystal structure of cAMP-dependent protein kinase catalytic subunit alpha in complex with peptide inhibitor PKI alpha (6-25)
3g51	Structural diversity of the active conformation of the N-terminal kinase domain of p90 ribosomal S6 kinase 2
3hdm	Crystal structure of serum and glucocorticoid-regulated kinase 1 in complex with compound 1
3hdn	Crystal structure of serum and glucocorticoid-regulated kinase 1 in complex with compound 2
3idb	Crystal structure of (108-268)RIIb:C holoenzyme of cAMP-dependent protein kinase
3idc	Crystal structure of (102-265)RIIb:C holoenzyme of cAMP-dependent protein kinase
3iw4	Crystal structure of PKC alpha in complex with NVP-AEB071
3j4q	Pseudo-atomic model of the AKAP18-PKA complex in a bent conformation derived from electron microscopy
3j4r	Pseudo-atomic model of the AKAP18-PKA Complex in a linear conformation derived from electron microscopy
3kkv	Structure of PKA with a protein Kinase B-selective inhibitor.
3krw	Human GRK2 in complex with Gbetgamma subunits and balanol (soak)
3krx	Human GRK2 in complex with Gbetgamma subunits and balanol (co-crystal)
3l9l	Crystal structure of pka with compound 36
3l9m	Crystal structure of PKAB3 (pka triple mutant V123A, L173M, Q181K) with compound 18
3l9n	crystal structure of PKAB3 (pka triple mutant V123A, L173M, Q181K) with compound 27
3mv5	Crystal structure of Akt-1-inhibitor complexes
3mvh	Crystal structure of Akt-1-inhibitor complexes
3mvj	Human cyclic AMP-dependent protein kinase PKA inhibitor complex
3ncz	X-Ray Co-structure of Rho-Associated Protein Kinase (ROCK1) with a potent 2H-isoquinolin-1-one inhibitor
3ndm	Crystal structure of Rho-Associated Protein Kinase (ROCK1) with a potent isoquinolone derivative
3nx8	human cAMP dependent protein kinase in complex with phenol
3nyn	Crystal Structure of G Protein-Coupled Receptor Kinase 6 in Complex with Sangivamycin
3nyo	Crystal Structure of G Protein-Coupled Receptor Kinase 6 in Complex with AMP
3o7l	Crystal Structure of phospholamban (1-19):PKA C-subunit:AMP-PNP:Mg2+ complex
3o96	Crystal Structure of Human AKT1 with an Allosteric Inhibitor
3ocb	Akt1 kinase domain with pyrrolopyrimidine inhibitor
3oog	human cAMP-dependent protein kinase in complex with a small fragment
3ovv	Human cAMP-dependent protein kinase in complex with an inhibitor
3ow3	Discovery of dihydrothieno- and dihydrofuropyrimidines as potent pan Akt inhibitors
3ow4	Discovery of dihydrothieno- and dihydrofuropyrimidines as potent pan Akt inhibitors
3owp	Human cAMP-dependent protein kinase in complex with an inhibitor
3oxt	Human cAMP-dependent protein kinase in complex with an inhibitor
3p0m	Human cAMP-dependent protein kinase in complex with an inhibitor
3pfq	Crystal Structure and Allosteric Activation of Protein Kinase C beta II
3poo	human cAMP-dependent protein kinase in complex with an inhibitor
3psc	Bovine GRK2 in complex with Gbetagamma subunits
3pvb	Crystal structure of (73-244)RIa:C holoenzyme of cAMP-dependent Protein kinase
3pvu	Bovine GRK2 in complex with Gbetagamma subunits and a selective kinase inhibitor (CMPD101)
3pvw	Bovine GRK2 in complex with Gbetagamma subunits and a selective kinase inhibitor (CMPD103A)
3qal	Crystal Structure of Arg280Ala mutant of Catalytic subunit of cAMP-dependent Protein Kinase
3qam	Crystal Structure of Glu208Ala mutant of catalytic subunit of cAMP-dependent protein kinase
3qc9	Crystal structure of cross-linked bovine GRK1 T8C/N480C double mutant complexed with ADP and Mg
3qfv	MRCK beta in complex with TPCA-1
3qkk	Spirochromane Akt Inhibitors
3qkl	Spirochromane Akt Inhibitors
3qkm	Spirocyclic sulfonamides as AKT inhibitors
3t8o	Rhodopsin kinase (GRK1) L166K mutant at 2.5A resolution
3tku	MRCK beta in complex with fasudil
3tnp	Structure and Allostery of the PKA RIIb Tetrameric Holoenzyme
3tnq	Structure and Allostery of the PKA RIIb Tetrameric Holoenzyme
3tv7	Human Rho-associated protein kinase 1 (ROCK 1) in COMPLEX WITH RKI1342
3twj	Rho-associated protein kinase 1 (ROCK 1) IN COMPLEX WITH RKI1447
3txo	PKC eta kinase in complex with a naphthyridine
3uzs	Structure of the C13.28 RNA Aptamer Bound to the G Protein-Coupled Receptor Kinase 2-Heterotrimeric G Protein Beta 1 and Gamma 2 Subunit Complex
3uzt	Structure of the C13.18 RNA Aptamer in Complex with G Protein-Coupled Receptor Kinase 2
3v5w	Human G Protein-Coupled Receptor Kinase 2 in Complex with Soluble Gbetagamma Subunits and Paroxetine
3v8s	Human RHO-ASSOCIATED PROTEIN KINASE 1 (ROCK 1) IN COMPLEX WITH INDAZOLE DERIVATIVE (COMPOUND 18)
3vqh	Bromine SAD partially resolves multiple binding modes for PKA inhibitor H-89
3we4	3WE4
3wf5	3WF5
3wf6	3WF6
3wf7	3WF7
3wf8	3WF8
3wf9	3WF9
3x2u	3X2U
3x2v	3X2V
3x2w	3X2W
3zh8	A novel small molecule aPKC inhibitor
3zo1	The Synthesis and Evaluation of Diazaspirocyclic Protein Kinase Inhibitors
3zo2	The Synthesis and Evaluation of Diazaspirocyclic Protein Kinase Inhibitors
3zo3	The Synthesis and Evaluation of Diazaspirocyclic Protein Kinase Inhibitors
3zo4	The Synthesis and Evaluation of Diazaspirocyclic Protein Kinase Inhibitors
4ae6	A Crystal Structure of the Sperm Specific Isoform of Protein Kinase A (PKA) Subunit CalphaS Reveals a Binding Pocket for Hydrophobic Moieties
4ae9	A Crystal Structure of the Sperm Specific Isoform of Protein Kinase A (PKA) Subunit CalphaS Reveals a Binding Pocket for Hydrophobic Moieties
4aw2	Crystal structure of CDC42 binding protein kinase alpha (MRCK alpha)
4axa	Structure of PKA-PKB chimera complexed with (1S)-2-amino-1-(4- chlorophenyl)-1-(4-(1H-pyrazol-4-yl)phenyl)ethan-1-ol
4c33	PKA-S6K1 Chimera Apo
4c34	PKA-S6K1 Chimera with Staurosporine bound
4c35	PKA-S6K1 Chimera with compound 1 (NU1085) bound
4c36	PKA-S6K1 Chimera with compound 15e (CCT147581) bound
4c37	PKA-S6K1 Chimera with compound 21a (CCT196539) bound
4c38	PKA-S6K1 Chimera with compound 21e (CCT239066) bound
4crs	Human Protein Kinase N2 (PKN2, PRKCL2) in complex with ATPgammaS
4dc2	Structure of PKC in Complex with a Substrate Peptide from Par-3
4dfx	Crystal structure of myristoylated K7C catalytic subunit of cAMP-dependent protein kinase in complex with SP20 and AMP-PNP
4dfy	Crystal structure of R194A mutant of cAMP-dependent protein kinase with unphosphorylated activation loop
4dfz	Crystal structure of myristoylated K7C catalytic subunit of cAMP-dependent protein kinase in complex with SP20
4dg0	Crystal structure of myristoylated WT catalytic subunit of cAMP-dependent protein kinase in complex with SP20 and AMP-PNP
4dg2	Crystal structure of myristoylated WT catalytic subunit of cAMP-dependent protein kinase in complex with SP20
4dg3	Crystal structure of R336A mutant of cAMP-dependent protein kinase with unphosphorylated turn motif.
4dh1	Low temperature X-ray structure of cAMP dependent Protein Kinase A catalytic subunit with low Mg2+, ATP and IP20
4dh3	Low temperature X-ray structure of cAMP dependent Protein Kinase A catalytic subunit with high Mg2+, ATP and IP20
4dh5	Room temperature X-ray structure of cAMP dependent Protein Kinase A catalytic subunit with high Mg2+, ADP, Phosphate, and IP20
4dh7	Low temperature X-ray structure of cAMP dependent Protein Kinase A catalytic subunit with high Mg2+, AMP-PNP and IP20'
4dh8	Room temperature X-ray structure of cAMP dependent Protein Kinase A catalytic subunit with high Mg2+, AMP-PNP and IP20
4din	Novel Localization and Quaternary Structure of the PKA RI beta Holoenzyme
4ejn	Crystal structure of autoinhibited form of AKT1 in complex with N-(4-(5-(3-acetamidophenyl)-2-(2-aminopyridin-3-yl)-3H-imidazo[4,5-b]pyridin-3-yl)benzyl)-3-fluorobenzamide
4ekk	Akt1 with AMP-PNP
4ekl	Akt1 with GDC0068
4gv1	PKB alpha in complex with AZD5363
4hpt	Crystal structure of the catalytic subunit of cAMP-dependent protein kinase displaying complete phosphoryl transfer of AMP-PNP onto a substrate peptide
4hpu	Crystal structure of the catalytic subunit of cAMP-dependent protein kinase displaying partial phosphoryl transfer of AMP-PNP onto a substrate peptide
4iac	X-RAY structure of cAMP dependent protein kinase A in compelx with HIGH MG2+ concentration, AMP-PCP AND pseudo-substrate peptide SP20
4iad	Low temperature X-ray Structure OF cAMP dependent protein kinase A in compelx with high Mg2+ concentration, ADP and phosphorylated peptide pSP20
4iaf	Room temperature X-ray Structure OF cAMP dependent protein kinase A in complex with high Mg2+ concentration, ADP and phosphorylated peptide pSP20
4iai	X-ray Structure of cAMP dependent protein kinase A in complex with high Ca2+ concentration, ADP and phosphorylated peptide pSP20
4iak	Low temperature X-ray structure of cAMP dependent protein kinase A in complex with high Sr2+ concentration, ADP and phosphorylated peptide pSP20
4iay	Room temperature X-ray Structure of cAMP dependent protein kinase A in complex with high Sr2+ concentration, ADP and phosphorylated peptide pSP20
4iaz	Structure of cAMP dependent protein kinase A in complex with high Ba2+ concentration, ADP and phosphorylated peptide pSP20
4ib0	X-ray Structure of cAMP dependent protein kinase A in complex with high Na+ concentration, ADP and phosphorylated peptide pSP20
4ib1	Structure of cAMP dependent protein kinase A in complex with high K+ concentration, ADP and phosphorylated peptide pSP20
4ib3	Structure of cAMP dependent protein kinase A in complex with ADP, phosphorylated peptide pSP20, and no metal
4ie9	Bovine PKA C-alpha in complex with 3-pyridylmethyl-5-methyl-1H-pyrazole-3-carboxylate
4ij9	Bovine PKA C-alpha in complex with 2-[[5-(4-pyridyl)-1H-1,2,4-triazol-3-yl]sulfanyl]-1-(2-thiophenyl)ethanone
4l42	Crystal structures of human p70S6K1-PIF
4l43	Crystal structures of human p70S6K1-T389A (form I)
4l44	Crystal structures of human p70S6K1-T389A (form II)
4l45	Crystal structures of human p70S6K1-T389E
4l46	Crystal structures of human p70S6K1-WT
4l6q	ROCK2 in complex with benzoxaborole
4l9i	Bovine G Protein Coupled Receptor Kinase 1 in Complex with Paroxetine
4lqp	4LQP
4lqq	4LQQ
4lqs	4LQS
4mk0	Crystal structure of G protein-coupled receptor kinase 2 in complex with a a rationally designed paroxetine derivative
4nts	4NTS
4ntt	4NTT
4nus	Rsk2 N-terminal kinase in complex with LJH685
4nw5	Rsk2 N-terminal kinase in complex with 2-amino-7-substituted benzoxazole compound 8
4nw6	Rsk2 N-terminal kinase in complex with 2-amino-7-substituted benzoxazole compound 27
4o21	4O21
4o22	4O22
4otd	4OTD
4otg	4OTG
4oth	4OTH
4oti	4OTI
4pni	4PNI
4pnk	4PNK
4q9z	4Q9Z
4ra4	4RA4
4ra5	4RA5
4tnb	4TNB
4tnd	4TND
4uak	4UAK
4ual	4UAL
4uj1	4UJ1
4uj2	4UJ2
4uj9	4UJ9
4uja	4UJA
4ujb	4UJB
4w7p	4W7P
4wb5	4WB5
4wb6	4WB6
4wb7	4WB7
4wb8	4WB8
4wbb	4WBB
4wbo	4WBO
4wih	4WIH
4wnk	4WNK
4wot	4WOT
4x6q	4X6Q
4x6r	4X6R
4xw4	4XW4
4xw5	4XW5
4xw6	4XW6
4yhj	4YHJ
4yvc	4YVC
4yve	4YVE
4yxr	4YXR
4yxs	4YXS
4z83	4Z83
4z84	4Z84
5bml	5BML
5bx6	5BX6
5bx7	5BX7
5d9k	5D9K
5d9l	5D9L
5dyk	5DYK
5f9e	5F9E
5he0	5HE0
5he1	5HE1
5he2	5HE2
5he3	5HE3
5izf	5IZF
5izj	5IZJ
5j5x	5J5X
5kcv	5KCV
5li1	5LI1
5li9	5LI9
5lih	5LIH
5loh	5LOH

Links (links to other resources describing this domain)

• INTERPRO: IPR000961