The domain within your query sequence starts at position 650 and ends at position 714; the E-value for the S_TK_X domain shown below is 3.79e-2.
RSLDWNSLLRQKAEFIPQLESEDDTSYFDTRSEKYHHMETEEEDDTNDEDFTVEIRQFSS CSHRF
S_TK_XExtension to Ser/Thr-type protein kinases |
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SMART accession number: | SM00133 |
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Description: | - |
Interpro abstract (IPR000961): | Protein phosphorylation, which plays a key role in most cellular activities, is a reversible process mediated by protein kinases and phosphoprotein phosphatases. Protein kinases catalyse the transfer of the gamma phosphate from nucleotide triphosphates (often ATP) to one or more amino acid residues in a protein substrate side chain, resulting in a conformational change affecting protein function. Phosphoprotein phosphatases catalyse the reverse process. Protein kinases fall into three broad classes, characterised with respect to substrate specificity [ (PUBMED:3291115) ]:
Protein kinase function is evolutionarily conserved from Escherichia coli to human [ (PUBMED:12471243) ]. Protein kinases play a role in a multitude of cellular processes, including division, proliferation, apoptosis, and differentiation [ (PUBMED:12368087) ]. Phosphorylation usually results in a functional change of the target protein by changing enzyme activity, cellular location, or association with other proteins. The catalytic subunits of protein kinases are highly conserved, and several structures have been solved [ (PUBMED:15078142) ], leading to large screens to develop kinase-specific inhibitors for the treatments of a number of diseases [ (PUBMED:15320712) ]. The AGC (cAMP-dependent, cGMP-dependent and protein kinase C) protein kinase family embraces a collection of protein kinases that display a high degree of sequence similarity within their respective kinase domains. AGC kinase proteins are characterised by three conserved phosphorylation sites that critically regulate their function. The first one is located in an activation loop in the centre of the kinase domain. The two other phosphorylation sites are located outside the kinase domain in a conserved region on its C-terminal side, the AGC-kinase C-terminal domain. These sites serves as phosphorylation-regulated switches to control both intra- and inter-molecular interactions. Without these priming phosphorylations, the kinases are catalytically inactive [ (PUBMED:12495431) (PUBMED:11709088) (PUBMED:15209375) ]. Several structures of the AGC-kinase C-terminal domain have been solved. The first phosphorylation site is located in a turn motif, the second one at the end of the domain in an hydrophobic pocket. In PKB the phosphorylated hydrophobic motif engages a hydrophobic groove within the N-lobe of the kinase domain which orders alpha helices close to the active site [ (PUBMED:12434148) ]. |
GO process: | protein phosphorylation (GO:0006468) |
GO function: | protein serine/threonine kinase activity (GO:0004674), ATP binding (GO:0005524) |
Family alignment: |
There are 38412 S_TK_X domains in 38361 proteins in SMART's nrdb database.
Click on the following links for more information.
- Evolution (species in which this domain is found)
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Taxonomic distribution of proteins containing S_TK_X domain.
This tree includes only several representative species. The complete taxonomic breakdown of all proteins with S_TK_X domain is also avaliable.
Click on the protein counts, or double click on taxonomic names to display all proteins containing S_TK_X domain in the selected taxonomic class.
- Disease (disease genes where sequence variants are found in this domain)
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SwissProt sequences and OMIM curated human diseases associated with missense mutations within the S_TK_X domain.
Protein Disease Rhodopsin kinase (Q15835) (SMART) OMIM:180381: Oguchi disease-2
OMIM:258100:Protein kinase C gamma type (P05129) (SMART) OMIM:176980: PROTEIN KINASE C, GAMMA; PRKCG - Metabolism (metabolic pathways involving proteins which contain this domain)
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Click the image to view the interactive version of the map in iPath% proteins involved KEGG pathway ID Description 6.60 map04010 MAPK signaling pathway 4.74 map04720 Long-term potentiation 4.74 map04910 Insulin signaling pathway 4.64 map04530 Tight junction 4.49 map04914 Progesterone-mediated oocyte maturation 4.20 map04310 Wnt signaling pathway 4.20 map04540 Gap junction 3.42 map04510 Focal adhesion 3.42 map04012 ErbB signaling pathway 3.37 map04020 Calcium signaling pathway 3.37 map04916 Melanogenesis 3.37 map04150 mTOR signaling pathway 3.13 map04210 Apoptosis 2.78 map04740 Olfactory transduction 2.59 map04370 VEGF signaling pathway 2.59 map05214 Glioma 2.59 map05223 Non-small cell lung cancer 2.25 map04670 Leukocyte transendothelial migration 2.25 map04730 Long-term depression 2.00 map05221 Acute myeloid leukemia 1.95 map04742 Taste transduction 1.95 map04912 GnRH signaling pathway 1.95 map04340 Hedgehog signaling pathway 1.66 map04350 TGF-beta signaling pathway 1.42 map04070 Phosphatidylinositol signaling system 1.42 map04650 Natural killer cell mediated cytotoxicity 1.17 map05222 Small cell lung cancer 1.17 map05213 Endometrial cancer 1.17 map04662 B cell receptor signaling pathway 1.17 map05212 Pancreatic cancer 1.17 map04630 Jak-STAT signaling pathway 1.17 map05220 Chronic myeloid leukemia 1.17 map04920 Adipocytokine signaling pathway 1.17 map04664 Fc epsilon RI signaling pathway 1.17 map05210 Colorectal cancer 1.17 map04620 Toll-like receptor signaling pathway 1.17 map05215 Prostate cancer 1.17 map04660 T cell receptor signaling pathway 1.17 map05211 Renal cell carcinoma 1.17 map05218 Melanoma 0.83 map04810 Regulation of actin cytoskeleton 0.83 map04360 Axon guidance 0.29 map00632 Benzoate degradation via CoA ligation 0.29 map00562 Inositol phosphate metabolism 0.24 map04111 Cell cycle - yeast This information is based on mapping of SMART genomic protein database to KEGG orthologous groups. Percentage points are related to the number of proteins with S_TK_X domain which could be assigned to a KEGG orthologous group, and not all proteins containing S_TK_X domain. Please note that proteins can be included in multiple pathways, ie. the numbers above will not always add up to 100%.
- Structure (3D structures containing this domain)
3D Structures of S_TK_X domains in PDB
PDB code Main view Title 1apm 2.0 ANGSTROM REFINED CRYSTAL STRUCTURE OF THE CATALYTIC SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE COMPLEXED WITH A PEPTIDE INHIBITOR AND DETERGENT 1atp 2.2 ANGSTROM REFINED CRYSTAL STRUCTURE OF THE CATALYTIC SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE COMPLEXED WITH MNATP AND A PEPTIDE INHIBITOR 1bkx A BINARY COMPLEX OF THE CATALYTIC SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE AND ADENOSINE FURTHER DEFINES CONFORMATIONAL FLEXIBILITY 1bx6 CRYSTAL STRUCTURE OF THE POTENT NATURAL PRODUCT INHIBITOR BALANOL IN COMPLEX WITH THE CATALYTIC SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE 1cdk CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT (E.C.2.7.1.37) (PROTEIN KINASE A) COMPLEXED WITH PROTEIN KINASE INHIBITOR PEPTIDE FRAGMENT 5-24 (PKI(5-24) ISOELECTRIC VARIANT CA) AND MN2+ ADENYLYL IMIDODIPHOSPHATE (MNAMP-PNP) AT PH 5.6 AND 7C AND 4C 1cmk CRYSTAL STRUCTURES OF THE MYRISTYLATED CATALYTIC SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE REVEAL OPEN AND CLOSED CONFORMATIONS 1ctp STRUCTURE OF THE MAMMALIAN CATALYTIC SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE AND AN INHIBITOR PEPTIDE DISPLAYS AN OPEN CONFORMATION 1fmo CRYSTAL STRUCTURE OF A POLYHISTIDINE-TAGGED RECOMBINANT CATALYTIC SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE COMPLEXED WITH THE PEPTIDE INHIBITOR PKI(5-24) AND ADENOSINE 1fot STRUCTURE OF THE UNLIGANDED CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT FROM SACCHAROMYCES CEREVISIAE 1gzk Molecular mechanism for the regulation of protein kinase B/Akt by hydrophobic motif phosphorylation 1gzn Structure of PKB kinase domain 1gzo Structure of protein kinase B unphosphorylated 1j3h Crystal structure of apoenzyme cAMP-dependent protein kinase catalytic subunit 1jbp Crystal Structure of the Catalytic Subunit of cAMP-dependent Protein Kinase Complexed with a Substrate Peptide, ADP and Detergent 1jlu Crystal Structure of the Catalytic Subunit of cAMP-dependent Protein Kinase Complexed with a Phosphorylated Substrate Peptide and Detergent 1l3r Crystal Structure of a Transition State Mimic of the Catalytic Subunit of cAMP-dependent Protein Kinase 1mrv crystal structure of an inactive Akt2 kinase domain 1mry crystal structure of an inactive akt2 kinase domain 1o6k Structure of activated form of PKB kinase domain S474D with GSK3 peptide and AMP-PNP 1o6l Crystal structure of an activated Akt/protein kinase B (PKB-PIF chimera) ternary complex with AMP-PNP and GSK3 peptide 1omw Crystal Structure of the complex between G Protein-Coupled Receptor Kinase 2 and Heterotrimeric G Protein beta 1 and gamma 2 subunits 1q24 PKA double mutant model of PKB in complex with MgATP 1q61 PKA triple mutant model of PKB 1q62 PKA double mutant model of PKB 1q8t The Catalytic Subunit of cAMP-dependent Protein Kinase (PKA) in Complex with Rho-kinase Inhibitor Y-27632 1q8u The Catalytic Subunit of cAMP-dependent Protein Kinase in Complex with Rho-kinase Inhibitor H-1152P 1q8w The Catalytic Subunit of cAMP-dependent Protein Kinase in Complex with Rho-kinase Inhibitor Fasudil (HA-1077) 1rdq Hydrolysis of ATP in the crystal of Y204A mutant of cAMP-dependent protein kinase 1re8 Crystal structure of cAMP-dependent protein kinase complexed with balanol analog 2 1rej Crystal structure of cAMP-dependent protein kinase complexed with balanol analog 1 1rek Crystal structure of cAMP-dependent protein kinase complexed with balanol analog 8 1smh Protein kinase A variant complex with completely ordered N-terminal helix 1stc CAMP-DEPENDENT PROTEIN KINASE, ALPHA-CATALYTIC SUBUNIT IN COMPLEX WITH STAUROSPORINE 1sve Crystal Structure of Protein Kinase A in Complex with Azepane Derivative 1 1svg Crystal Structure of Protein Kinase A in Complex with Azepane Derivative 4 1svh Crystal Structure of Protein Kinase A in Complex with Azepane Derivative 8 1syk Crystal structure of E230Q mutant of cAMP-dependent protein kinase reveals unexpected apoenzyme conformation 1szm DUAL BINDING MODE OF BISINDOLYLMALEIMIDE 2 TO PROTEIN KINASE A (PKA) 1veb Crystal Structure of Protein Kinase A in Complex with Azepane Derivative 5 1xh4 Crystal Structures of Protein Kinase B Selective Inhibitors in Complex with Protein Kinase A and Mutants 1xh5 Crystal Structures of Protein Kinase B Selective Inhibitors in Complex with Protein Kinase A and Mutants 1xh6 Crystal Structures of Protein Kinase B Selective Inhibitors in Complex with Protein Kinase A and Mutants 1xh7 Crystal Structures of Protein Kinase B Selective Inhibitors in Complex with Protein Kinase A and Mutants 1xh8 Crystal Structures of Protein Kinase B Selective Inhibitors in Complex with Protein Kinase A and Mutants 1xh9 Crystal Structures of Protein Kinase B Selective Inhibitors in Complex with Protein Kinase A and Mutants 1xha Crystal Structures of Protein Kinase B Selective Inhibitors in Complex with Protein Kinase A and Mutants 1xjd Crystal Structure of PKC-theta complexed with Staurosporine at 2A resolution 1ydr STRUCTURE OF CAMP-DEPENDENT PROTEIN KINASE, ALPHA-CATALYTIC SUBUNIT IN COMPLEX WITH H7 PROTEIN KINASE INHIBITOR 1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE 1yds STRUCTURE OF CAMP-DEPENDENT PROTEIN KINASE, ALPHA-CATALYTIC SUBUNIT IN COMPLEX WITH H8 PROTEIN KINASE INHIBITOR [N-(2-METHYLAMINO)ETHYL]-5-ISOQUINOLINESULFONAMIDE 1ydt STRUCTURE OF CAMP-DEPENDENT PROTEIN KINASE, ALPHA-CATALYTIC SUBUNIT IN COMPLEX WITH H89 PROTEIN KINASE INHIBITOR N-[2-(4-BROMOCINNAMYLAMINO)ETHYL]-5-ISOQUINOLINE 1ym7 G Protein-Coupled Receptor Kinase 2 (GRK2) 1zrz Crystal Structure of the Catalytic Domain of Atypical Protein Kinase C-iota 2acx Crystal Structure of G protein coupled receptor kinase 6 bound to AMPPNP 2bcj Crystal Structure of G Protein-Coupled Receptor Kinase 2 in Complex with Galpha-q and Gbetagamma Subunits 2c1a Structure of cAMP-dependent protein kinase complexed with Isoquinoline-5-sulfonic acid (2-(2-(4-chlorobenzyloxy)ethylamino) ethyl)amide 2c1b Structure of cAMP-dependent protein kinase complexed with (4R,2S)-5'-( 4-(4-Chlorobenzyloxy)pyrrolidin-2-ylmethanesulfonyl)isoquinoline 2cpk CRYSTAL STRUCTURE OF THE CATALYTIC SUBUNIT OF CYCLIC ADENOSINE MONOPHOSPHATE-DEPENDENT PROTEIN KINASE 2erz Crystal Structure of c-AMP Dependent Kinase (PKA) bound to hydroxyfasudil 2esm Crystal Structure of ROCK 1 bound to fasudil 2etk Crystal Structure of ROCK 1 bound to hydroxyfasudil 2etr Crystal Structure of ROCK I bound to Y-27632 2f2u crystal structure of the Rho-kinase kinase domain 2f7e PKA complexed with (S)-2-(1H-Indol-3-yl)-1-(5-isoquinolin-6-yl-pyridin-3-yloxymethyl-etylamine 2f7x Protein Kinase A bound to (S)-2-(1H-Indol-3-yl)-1-[5-((E)-2-pyridin-4-yl-vinyl)-pyridin-3-yloxymethyl]-ethylamine 2f7z Protein Kinase A bound to (R)-1-(1H-Indol-3-ylmethyl)-2-(2-pyridin-4-yl-[1,7]naphtyridin-5-yloxy)-ehylamine 2gfc cAMP-dependent protein kinase PKA catalytic subunit with PKI-5-24 2gnf Protein kinase A fivefold mutant model of Rho-kinase with Y-27632 2gng Protein kinase A fivefold mutant model of Rho-kinase 2gnh PKA five fold mutant model of Rho-kinase with H1152P 2gni PKA fivefold mutant model of Rho-kinase with inhibitor Fasudil (HA1077) 2gnj PKA three fold mutant model of Rho-kinase with Y-27632 2gnl PKA threefold mutant model of Rho-kinase with inhibitor H-1152P 2gu8 Discovery of 2-Pyrimidyl-5-Amidothiophenes as Novel and Potent Inhibitors for AKT: Synthesis and SAR Studies 2h9v Structural basis for induced-fit binding of Rho-kinase to the inhibitor Y27632 2i0e Structure of catalytic domain of human protein kinase C beta II complexed with a bisindolylmaleimide inhibitor 2jdo STRUCTURE OF PKB-BETA (AKT2) COMPLEXED WITH ISOQUINOLINE-5-SULFONIC ACID (2-(2-(4-CHLOROBENZYLOXY) ETHYLAMINO)ETHYL)AMIDE 2jdr STRUCTURE OF PKB-BETA (AKT2) COMPLEXED WITH THE INHIBITOR A-443654 2jds Structure of cAMP-dependent protein kinase complexed with A-443654 2jdt Structure of PKA-PKB chimera complexed with ISOQUINOLINE-5-SULFONIC ACID (2-(2-(4-CHLOROBENZYLOXY) ETHYLAMINO)ETHYL)AMIDE 2jdv Structure of PKA-PKB chimera complexed with A-443654 2jed The crystal structure of the kinase domain of the protein kinase C theta in complex with NVP-XAA228 at 2.32A resolution. 2oh0 Crystal structure of Protein Kinase A in complex with Pyridine-Pyrazolopyridine Based Inhibitors 2ojf Crystal structure of Protein Kinase A in complex with Pyridine-Pyrazolopyridine based inhibitors 2qcs A complex structure between the Catalytic and Regulatory subunit of Protein Kinase A that represents the inhibited state 2qur Crystal Structure of F327A/K285P Mutant of cAMP-dependent Protein Kinase 2qvs Crystal Structure of Type IIa Holoenzyme of cAMP-dependent Protein Kinase 2r5t Crystal Structure of Inactive Serum and Glucocorticoid- Regulated Kinase 1 in Complex with AMP-PNP 2uvx Structure of PKA-PKB chimera complexed with 7-azaindole 2uvy Structure of PKA-PKB chimera complexed with methyl-(4-(9H-purin-6-yl)- benzyl)-amine 2uvz Structure of PKA-PKB chimera complexed with C-Phenyl-C-(4-(9H-purin-6- yl)-phenyl)-methylamine 2uw0 Structure of PKA-PKB chimera complexed with 6-(4-(4-(4-Chloro-phenyl) -piperidin-4-yl)-phenyl)-9H-purine 2uw3 Structure of PKA-PKB chimera complexed with 5-methyl-4-phenyl-1H- pyrazole 2uw4 Structure of PKA-PKB chimera complexed with 2-(4-(5-methyl-1H-pyrazol- 4-yl)-phenyl)-ethylamine 2uw5 Structure of PKA-PKB chimera complexed with (R)-2-(4-chloro-phenyl)- 2-(4-1H-pyrazol-4-yl)-phenyl)-ethylamine 2uw6 Structure of PKA-PKB chimera complexed with (S)-2-(4-chloro-phenyl)- 2-(4-1H-pyrazol-4-yl)-phenyl)-ethylamine 2uw7 Structure of PKA-PKB chimera complexed with 4-(4-chloro-phenyl)-4-(4- (1H-pyrazol-4-yl)-phenyl)-piperidine 2uw8 Structure of PKA-PKB chimera complexed with 2-(4-chloro-phenyl)-2- phenyl-ethylamine 2uw9 STRUCTURE OF PKB-BETA (AKT2) COMPLEXED WITH 4-(4-chloro-phenyl)-4-(4-( 1H-pyrazol-4-yl)-phenyl)-piperidine 2uzt PKA structures of AKT, indazole-pyridine inhibitors 2uzu PKA structures of indazole-pyridine series of AKT inhibitors 2uzv PKA structures of indazole-pyridine series of AKT inhibitors 2uzw PKA structures of indazole-pyridine series of AKT inhibitors 2v55 Mechanism of multi-site phosphorylation from a ROCK-I:RhoE complex structure 2vd5 Structure of Human Myotonic Dystrophy Protein Kinase in Complex with the Bisindoylmaleide inhibitor BIM VIII 2vnw Structure of PKA-PKB chimera complexed with (1-(9H-Purin-6-yl) piperidin-4-yl)methanamine 2vny Structure of PKA-PKB chimera complexed with (1-(9H-Purin-6-yl) piperidin-4-yl)amine 2vo0 Structure of PKA-PKB chimera complexed with C-(4-(4-Chlorophenyl)-1-( 7H-pyrrolo(2,3-d)pyrimidin-4-yl)piperidin-4-yl)methylamine 2vo3 Structure of PKA-PKB chimera complexed with C-(4-(4-Chlorobenzyl)-1-( 7H-pyrrolo(2,3-d)pyrimidin-4-yl)piperidin-4-yl)methylamine 2vo6 Structure of PKA-PKB chimera complexed with 4-(4-Chlorobenzyl)-1-(7H- pyrrolo(2,3-d)pyrimidin-4-yl)piperidin-4-ylamine 2vo7 Structure of PKA complexed with 4-(4-Chlorobenzyl)-1-(7H-pyrrolo(2,3- d)pyrimidin-4-yl)piperidin-4-ylamine 2x39 Structure of 4-Amino-N-(4-chlorobenzyl)-1-(7H-pyrrolo(2,3-d)pyrimidin- 4-yl)piperidine-4-carboxamide bound to PKB 2xh5 Structure of 4-(4-tert-Butylbenzyl)-1-(7H-pyrrolo(2,3-d)pyrimidin-4- yl)piperidin-4-amine bound to PKB 2z7q Crystal structure of the N-terminal kinase domain of human RSK-1 bound to AMP-PCP 2z7r Crystal Structure of the N-terminal Kinase Domain of Human RSK1 bound to Staurosporine 2z7s Crystal Structure of the N-terminal Kinase Domain of Human RSK1 bound to Purvalnol A 3a60 Crystal structure of unphosphorylated p70S6K1 (Form I) 3a61 Crystal structure of unphosphorylated p70S6K1 (Form II) 3a62 Crystal structure of phosphorylated p70S6K1 3a8w Crystal Structure of PKCiota kinase domain 3a8x Crystal Structure of PKCiota kinase domain 3ag9 Complex of PKA with the bisubstrate protein kinase inhibitor ARC-1012 3agl Complex of PKA with the bisubstrate protein kinase inhibitor ARC-1039 3agm Complex of PKA with the bisubstrate protein kinase inhibitor ARC-670 3ama Protein kinase A sixfold mutant model of Aurora B with inhibitor JNJ-7706621 3amb Protein kinase A sixfold mutant model of Aurora B with inhibitor VX-680 3bwj Complex of PKA with the bisubstrate protein kinase inhibitor lead compound Arc-1034 3c4w Crystal Structure of G protein coupled receptor kinase 1 bound to ATP and magnesium chloride at 2.7A 3c4x Crystal Structure of G protein coupled receptor kinase 1 bound to ATP and magnesium chloride at 2.9A 3c4y Crystal Structure of Apo form of G protein coupled receptor kinase 1 at 7.51A 3c4z Crystal structure of G protein coupled receptor kinase 1 bound to ADP and magnesium chloride at 1.84A 3c50 Crystal Structure of G protein coupled receptor kinase 1 bound to ADP and magnesium chloride at 2.6A 3c51 Crystal structure of G protein coupled receptor kinase 1 bound to ADP and magnesium chloride at 3.55A 3cik Human GRK2 in Complex with Gbetagamma subunits 3cqu Crystal Structure of Akt-1 complexed with substrate peptide and inhibitor 3cqw Crystal Structure of Akt-1 complexed with substrate peptide and inhibitor 3d0e Crystal structure of human Akt2 in complex with GSK690693 3d9v CRYSTAL STRUCTURE OF ROCK I BOUND TO H-1152P A DI-METHYLATED VARIANT OF FASUDIL 3dnd cAMP-dependent protein kinase PKA catalytic subunit with PKI-5-24 3dne cAMP-dependent protein kinase PKA catalytic subunit with PKI-5-24 3e87 Crystal structures of the kinase domain of AKT2 in complex with ATP-competitive inhibitors 3e88 Crystal structures of the kinase domain of AKT2 in complex with ATP-competitive inhibitors 3e8c Crystal structures of the kinase domain of PKA in complex with ATP-competitive inhibitors 3e8d Crystal structures of the kinase domain of AKT2 in complex with ATP-competitive inhibitors 3e8e Crystal structures of the kinase domain of PKA in complex with ATP-competitive inhibitors 3fhi Crystal structure of a complex between the catalytic and regulatory (RI{alpha}) subunits of PKA 3fjq Crystal structure of cAMP-dependent protein kinase catalytic subunit alpha in complex with peptide inhibitor PKI alpha (6-25) 3g51 Structural diversity of the active conformation of the N-terminal kinase domain of p90 ribosomal S6 kinase 2 3hdm Crystal structure of serum and glucocorticoid-regulated kinase 1 in complex with compound 1 3hdn Crystal structure of serum and glucocorticoid-regulated kinase 1 in complex with compound 2 3idb Crystal structure of (108-268)RIIb:C holoenzyme of cAMP-dependent protein kinase 3idc Crystal structure of (102-265)RIIb:C holoenzyme of cAMP-dependent protein kinase 3iw4 Crystal structure of PKC alpha in complex with NVP-AEB071 3j4q Pseudo-atomic model of the AKAP18-PKA complex in a bent conformation derived from electron microscopy 3j4r Pseudo-atomic model of the AKAP18-PKA Complex in a linear conformation derived from electron microscopy 3kkv Structure of PKA with a protein Kinase B-selective inhibitor. 3krw Human GRK2 in complex with Gbetgamma subunits and balanol (soak) 3krx Human GRK2 in complex with Gbetgamma subunits and balanol (co-crystal) 3l9l Crystal structure of pka with compound 36 3l9m Crystal structure of PKAB3 (pka triple mutant V123A, L173M, Q181K) with compound 18 3l9n crystal structure of PKAB3 (pka triple mutant V123A, L173M, Q181K) with compound 27 3mv5 Crystal structure of Akt-1-inhibitor complexes 3mvh Crystal structure of Akt-1-inhibitor complexes 3mvj Human cyclic AMP-dependent protein kinase PKA inhibitor complex 3ncz X-Ray Co-structure of Rho-Associated Protein Kinase (ROCK1) with a potent 2H-isoquinolin-1-one inhibitor 3ndm Crystal structure of Rho-Associated Protein Kinase (ROCK1) with a potent isoquinolone derivative 3nx8 human cAMP dependent protein kinase in complex with phenol 3nyn Crystal Structure of G Protein-Coupled Receptor Kinase 6 in Complex with Sangivamycin 3nyo Crystal Structure of G Protein-Coupled Receptor Kinase 6 in Complex with AMP 3o7l Crystal Structure of phospholamban (1-19):PKA C-subunit:AMP-PNP:Mg2+ complex 3o96 Crystal Structure of Human AKT1 with an Allosteric Inhibitor 3ocb Akt1 kinase domain with pyrrolopyrimidine inhibitor 3oog human cAMP-dependent protein kinase in complex with a small fragment 3ovv Human cAMP-dependent protein kinase in complex with an inhibitor 3ow3 Discovery of dihydrothieno- and dihydrofuropyrimidines as potent pan Akt inhibitors 3ow4 Discovery of dihydrothieno- and dihydrofuropyrimidines as potent pan Akt inhibitors 3owp Human cAMP-dependent protein kinase in complex with an inhibitor 3oxt Human cAMP-dependent protein kinase in complex with an inhibitor 3p0m Human cAMP-dependent protein kinase in complex with an inhibitor 3pfq Crystal Structure and Allosteric Activation of Protein Kinase C beta II 3poo human cAMP-dependent protein kinase in complex with an inhibitor 3psc Bovine GRK2 in complex with Gbetagamma subunits 3pvb Crystal structure of (73-244)RIa:C holoenzyme of cAMP-dependent Protein kinase 3pvu Bovine GRK2 in complex with Gbetagamma subunits and a selective kinase inhibitor (CMPD101) 3pvw Bovine GRK2 in complex with Gbetagamma subunits and a selective kinase inhibitor (CMPD103A) 3qal Crystal Structure of Arg280Ala mutant of Catalytic subunit of cAMP-dependent Protein Kinase 3qam Crystal Structure of Glu208Ala mutant of catalytic subunit of cAMP-dependent protein kinase 3qc9 Crystal structure of cross-linked bovine GRK1 T8C/N480C double mutant complexed with ADP and Mg 3qfv MRCK beta in complex with TPCA-1 3qkk Spirochromane Akt Inhibitors 3qkl Spirochromane Akt Inhibitors 3qkm Spirocyclic sulfonamides as AKT inhibitors 3t8o Rhodopsin kinase (GRK1) L166K mutant at 2.5A resolution 3tku MRCK beta in complex with fasudil 3tnp Structure and Allostery of the PKA RIIb Tetrameric Holoenzyme 3tnq Structure and Allostery of the PKA RIIb Tetrameric Holoenzyme 3tv7 Human Rho-associated protein kinase 1 (ROCK 1) in COMPLEX WITH RKI1342 3twj Rho-associated protein kinase 1 (ROCK 1) IN COMPLEX WITH RKI1447 3txo PKC eta kinase in complex with a naphthyridine 3uzs Structure of the C13.28 RNA Aptamer Bound to the G Protein-Coupled Receptor Kinase 2-Heterotrimeric G Protein Beta 1 and Gamma 2 Subunit Complex 3uzt Structure of the C13.18 RNA Aptamer in Complex with G Protein-Coupled Receptor Kinase 2 3v5w Human G Protein-Coupled Receptor Kinase 2 in Complex with Soluble Gbetagamma Subunits and Paroxetine 3v8s Human RHO-ASSOCIATED PROTEIN KINASE 1 (ROCK 1) IN COMPLEX WITH INDAZOLE DERIVATIVE (COMPOUND 18) 3vqh Bromine SAD partially resolves multiple binding modes for PKA inhibitor H-89 3we4 3WE4 3wf5 3WF5 3wf6 3WF6 3wf7 3WF7 3wf8 3WF8 3wf9 3WF9 3x2u 3X2U 3x2v 3X2V 3x2w 3X2W 3zh8 A novel small molecule aPKC inhibitor 3zo1 The Synthesis and Evaluation of Diazaspirocyclic Protein Kinase Inhibitors 3zo2 The Synthesis and Evaluation of Diazaspirocyclic Protein Kinase Inhibitors 3zo3 The Synthesis and Evaluation of Diazaspirocyclic Protein Kinase Inhibitors 3zo4 The Synthesis and Evaluation of Diazaspirocyclic Protein Kinase Inhibitors 4ae6 A Crystal Structure of the Sperm Specific Isoform of Protein Kinase A (PKA) Subunit CalphaS Reveals a Binding Pocket for Hydrophobic Moieties 4ae9 A Crystal Structure of the Sperm Specific Isoform of Protein Kinase A (PKA) Subunit CalphaS Reveals a Binding Pocket for Hydrophobic Moieties 4aw2 Crystal structure of CDC42 binding protein kinase alpha (MRCK alpha) 4axa Structure of PKA-PKB chimera complexed with (1S)-2-amino-1-(4- chlorophenyl)-1-(4-(1H-pyrazol-4-yl)phenyl)ethan-1-ol 4c33 PKA-S6K1 Chimera Apo 4c34 PKA-S6K1 Chimera with Staurosporine bound 4c35 PKA-S6K1 Chimera with compound 1 (NU1085) bound 4c36 PKA-S6K1 Chimera with compound 15e (CCT147581) bound 4c37 PKA-S6K1 Chimera with compound 21a (CCT196539) bound 4c38 PKA-S6K1 Chimera with compound 21e (CCT239066) bound 4crs Human Protein Kinase N2 (PKN2, PRKCL2) in complex with ATPgammaS 4dc2 Structure of PKC in Complex with a Substrate Peptide from Par-3 4dfx Crystal structure of myristoylated K7C catalytic subunit of cAMP-dependent protein kinase in complex with SP20 and AMP-PNP 4dfy Crystal structure of R194A mutant of cAMP-dependent protein kinase with unphosphorylated activation loop 4dfz Crystal structure of myristoylated K7C catalytic subunit of cAMP-dependent protein kinase in complex with SP20 4dg0 Crystal structure of myristoylated WT catalytic subunit of cAMP-dependent protein kinase in complex with SP20 and AMP-PNP 4dg2 Crystal structure of myristoylated WT catalytic subunit of cAMP-dependent protein kinase in complex with SP20 4dg3 Crystal structure of R336A mutant of cAMP-dependent protein kinase with unphosphorylated turn motif. 4dh1 Low temperature X-ray structure of cAMP dependent Protein Kinase A catalytic subunit with low Mg2+, ATP and IP20 4dh3 Low temperature X-ray structure of cAMP dependent Protein Kinase A catalytic subunit with high Mg2+, ATP and IP20 4dh5 Room temperature X-ray structure of cAMP dependent Protein Kinase A catalytic subunit with high Mg2+, ADP, Phosphate, and IP20 4dh7 Low temperature X-ray structure of cAMP dependent Protein Kinase A catalytic subunit with high Mg2+, AMP-PNP and IP20' 4dh8 Room temperature X-ray structure of cAMP dependent Protein Kinase A catalytic subunit with high Mg2+, AMP-PNP and IP20 4din Novel Localization and Quaternary Structure of the PKA RI beta Holoenzyme 4ejn Crystal structure of autoinhibited form of AKT1 in complex with N-(4-(5-(3-acetamidophenyl)-2-(2-aminopyridin-3-yl)-3H-imidazo[4,5-b]pyridin-3-yl)benzyl)-3-fluorobenzamide 4ekk Akt1 with AMP-PNP 4ekl Akt1 with GDC0068 4gv1 PKB alpha in complex with AZD5363 4hpt Crystal structure of the catalytic subunit of cAMP-dependent protein kinase displaying complete phosphoryl transfer of AMP-PNP onto a substrate peptide 4hpu Crystal structure of the catalytic subunit of cAMP-dependent protein kinase displaying partial phosphoryl transfer of AMP-PNP onto a substrate peptide 4iac X-RAY structure of cAMP dependent protein kinase A in compelx with HIGH MG2+ concentration, AMP-PCP AND pseudo-substrate peptide SP20 4iad Low temperature X-ray Structure OF cAMP dependent protein kinase A in compelx with high Mg2+ concentration, ADP and phosphorylated peptide pSP20 4iaf Room temperature X-ray Structure OF cAMP dependent protein kinase A in complex with high Mg2+ concentration, ADP and phosphorylated peptide pSP20 4iai X-ray Structure of cAMP dependent protein kinase A in complex with high Ca2+ concentration, ADP and phosphorylated peptide pSP20 4iak Low temperature X-ray structure of cAMP dependent protein kinase A in complex with high Sr2+ concentration, ADP and phosphorylated peptide pSP20 4iay Room temperature X-ray Structure of cAMP dependent protein kinase A in complex with high Sr2+ concentration, ADP and phosphorylated peptide pSP20 4iaz Structure of cAMP dependent protein kinase A in complex with high Ba2+ concentration, ADP and phosphorylated peptide pSP20 4ib0 X-ray Structure of cAMP dependent protein kinase A in complex with high Na+ concentration, ADP and phosphorylated peptide pSP20 4ib1 Structure of cAMP dependent protein kinase A in complex with high K+ concentration, ADP and phosphorylated peptide pSP20 4ib3 Structure of cAMP dependent protein kinase A in complex with ADP, phosphorylated peptide pSP20, and no metal 4ie9 Bovine PKA C-alpha in complex with 3-pyridylmethyl-5-methyl-1H-pyrazole-3-carboxylate 4ij9 Bovine PKA C-alpha in complex with 2-[[5-(4-pyridyl)-1H-1,2,4-triazol-3-yl]sulfanyl]-1-(2-thiophenyl)ethanone 4l42 Crystal structures of human p70S6K1-PIF 4l43 Crystal structures of human p70S6K1-T389A (form I) 4l44 Crystal structures of human p70S6K1-T389A (form II) 4l45 Crystal structures of human p70S6K1-T389E 4l46 Crystal structures of human p70S6K1-WT 4l6q ROCK2 in complex with benzoxaborole 4l9i Bovine G Protein Coupled Receptor Kinase 1 in Complex with Paroxetine 4lqp 4LQP 4lqq 4LQQ 4lqs 4LQS 4mk0 Crystal structure of G protein-coupled receptor kinase 2 in complex with a a rationally designed paroxetine derivative 4nts 4NTS 4ntt 4NTT 4nus Rsk2 N-terminal kinase in complex with LJH685 4nw5 Rsk2 N-terminal kinase in complex with 2-amino-7-substituted benzoxazole compound 8 4nw6 Rsk2 N-terminal kinase in complex with 2-amino-7-substituted benzoxazole compound 27 4o21 4O21 4o22 4O22 4otd 4OTD 4otg 4OTG 4oth 4OTH 4oti 4OTI 4pni 4PNI 4pnk 4PNK 4q9z 4Q9Z 4ra4 4RA4 4ra5 4RA5 4tnb 4TNB 4tnd 4TND 4uak 4UAK 4ual 4UAL 4uj1 4UJ1 4uj2 4UJ2 4uj9 4UJ9 4uja 4UJA 4ujb 4UJB 4w7p 4W7P 4wb5 4WB5 4wb6 4WB6 4wb7 4WB7 4wb8 4WB8 4wbb 4WBB 4wbo 4WBO 4wih 4WIH 4wnk 4WNK 4wot 4WOT 4x6q 4X6Q 4x6r 4X6R 4xw4 4XW4 4xw5 4XW5 4xw6 4XW6 4yhj 4YHJ 4yvc 4YVC 4yve 4YVE 4yxr 4YXR 4yxs 4YXS 4z83 4Z83 4z84 4Z84 5bml 5BML 5bx6 5BX6 5bx7 5BX7 5d9k 5D9K 5d9l 5D9L 5dyk 5DYK 5f9e 5F9E 5he0 5HE0 5he1 5HE1 5he2 5HE2 5he3 5HE3 5izf 5IZF 5izj 5IZJ 5j5x 5J5X 5kcv 5KCV 5li1 5LI1 5li9 5LI9 5lih 5LIH 5loh 5LOH - Links (links to other resources describing this domain)
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INTERPRO IPR000961