The domain within your query sequence starts at position 109 and ends at position 308; the E-value for the TSPc domain shown below is 5.72e-69.

WARNING!
Some of the required catalytic sites were not detected in this domain. It is probably inactive! Check the literature (PubMed 21576514 ) for details.

Catalytic residues
Position		Amino acid	Present?
Domain	Protein
129	237	S	No

TREELLAQIQRNIRHEVLEGNVGYLRVDDLPGQEVLSELGEFLVSHVWRQLMSTSSLVLD
LRHCSGGHFSGIPYVISYLHPGNTVMHVDTVYDRPSNTTTEIWTLPEVLGERYSADKDVV
VLTSGHTGGVAEDIAYILKQMRRAIVVGERTEGGALDLQKLRIGQSNFFLTVPVSRSLGP
LGGGGQTWEGSGVLPCVGTP

TSPc

tail specific protease

• SMART accession number: SM00245
• Description: tail specific protease
• Interpro abstract (IPR005151):

  This entry represents a domain found in the tail-specific proteases, such as retinol-binding protein 3 (also known as IRBP) from animals, C-terminal processing peptidases from algae and tricorn proteases from archaea. This domain share structural similarity with the crotonase fold that is formed from repeated beta/beta/alpha units, which comprises two perpendicular beta-sheet surrounded by alpha-helices.

  The C-terminal processing peptidases have different substrates in different species, including processing of D1 protein of the photosystem II reaction centre in higher plants [ (PUBMED:8702985) ], and cleavage of a peptide of 11 residues from the precursor form of penicillin-binding protein in Escherichia coli [ (PUBMED:1856173) ].

  The tricorn protease is responsible for degrading oligopeptides, probably derived from the proteasome. Its crystal structure has been resolved to 2 A resolution [ (PUBMED:11719810) ].

• GO process: proteolysis (GO:0006508)
• GO function: serine-type peptidase activity (GO:0008236)

There are 36024 TSPc domains in 35205 proteins in SMART's nrdb database.

Structure (3D structures containing this domain)

3D Structures of TSPc domains in PDB

PDB code	Title
1fc6	PHOTOSYSTEM II D1 C-TERMINAL PROCESSING PROTEASE
1fc7	PHOTOSYSTEM II D1 C-TERMINAL PROCESSING PROTEASE
1fc9	PHOTOSYSTEM II D1 C-TERMINAL PROCESSING PROTEASE
1fcf	PHOTOSYSTEM II D1 C-TERMINAL PROCESSING PROTEASE
1j7x	CRYSTAL STRUCTURE OF A FUNCTIONAL UNIT OF INTERPHOTORECEPTOR RETINOID-BINDING PROTEIN (IRBP)
1k32	Crystal structure of the tricorn protease
1n6d	Tricorn protease in complex with tetrapeptide chloromethyl ketone derivative
1n6e	tricorn protease in complex with a tridecapeptide chloromethyl ketone derivative
1n6f	tricorn protease in complex with Z-Phe-diketo-Arg-Glu-Phe
3dja	Crystal Structure of cpaf solved with MAD
3dor	Crystal Structure of mature CPAF
3dpm	Structure of mature CPAF complexed with lactacystin
3dpn	Crystal Structure of cpaf s499a mutant
3k50	Crystal structure of Putative S41 protease (YP_211611.1) from Bacteroides fragilis NCTC 9343 at 2.00 A resolution
4c2c	Crystal structure of the protease CtpB in an active state
4c2d	Crystal structure of the protease CtpB in an active state
4c2e	Crystal structure of the protease CtpB(S309A) present in a resting state
4c2f	Crystal structure of the CtpB R168A mutant present in an active conformation
4c2g	Crystal structure of CtpB(S309A) in complex with a peptide having a Val-Pro-Ala C-terminus
4c2h	Crystal structure of the CtpB(V118Y) mutant
4ghn	Crystal structure of a hypothetical protein (BACUNI_00178) from Bacteroides uniformis ATCC 8492 at 1.50 A resolution
4l8k	Crystal structure of a putative peptidase (PARMER_02772) from Parabacteroides merdae ATCC 43184 at 2.26 A resolution
4lur	4LUR
4ql6	4QL6
4y68	4Y68

Links (links to other resources describing this domain)

• INTERPRO: IPR005151