Consensus terms for the CASH domain

O28859/26-134    RILGFLGILLVMLII---------------PVHGAVIVV----------PDNKTIQEVID
CONSENSUS/80%    h..G.hh....h.......................shhh...............t.h.h.
CONSENSUS/65%    hh.Gthh.ththt..h..............htstsshhl..........ts.pssshshp
CONSENSUS/50%    tssGsshpststshph.hh...........tssssusll.........hssspssslslp


O28859/26-134    SA------SDGDTVVV---------------RDGVYS-----------------------
CONSENSUS/80%    t.........G.hh...................Gh..t......................
CONSENSUS/65%    s.t......pGhhht.................sGhhhpt..t..................
CONSENSUS/50%    uss.....spGsphss.............tthsGsslsshssthh...............


O28859/26-134    --------------VYLNITKSITLRS-------------ENGTANCILEA---------
CONSENSUS/80%    ...............h.N........................G.................
CONSENSUS/65%    ...........t.hhhtNhhhtt.................ttGhhhpsstt.........
CONSENSUS/50%    ..........tpshhhsNsthst.................ssGlshssssps........


O28859/26-134    --------STNDDVIEVHADFVT------ITGFTIRNGN---------------------
CONSENSUS/80%    .........tN.h.................tG.hh.t..t....................
CONSENSUS/65%    .......h.tNph.st.............ssGhhhts.sssph.tt..............
CONSENSUS/50%    ......thtsNphpspt............usGshhssssusslsssph.ts.........


O28859/26-134    -DDGVDVE
CONSENSUS/80%    ..tG....
CONSENSUS/65%    .tsGhhhh
CONSENSUS/50%    .ssGltss

The grouping of amino acids to classes and class abbreviation (the key) used within consensus sequences are shown below:

ClassKeyResidues
alcoholoS,T
aliphaticlI,L,V
any.A,C,D,E,F,G,H,I,K,L,M,N,P,Q,R,S,T,V,W,Y
aromaticaF,H,W,Y
chargedcD,E,H,K,R
hydrophobichA,C,F,G,H,I,K,L,M,R,T,V,W,Y
negative-D,E
polarpC,D,E,H,K,N,Q,R,S,T
positive+H,K,R
smallsA,C,D,G,N,P,S,T,V
tinyuA,G,S
turnliketA,C,D,E,G,H,K,N,Q,R,S,T