Consensus terms for the TLC domain

CLN8_Hs          VFWDLAATRAVFGVQSTAAGLWALLGDP---VLHA------------DKARGQQNWCWFH
CONSENSUS/80%    .ph.p...phh.hh.uhhhshhhhh.........p........................h
CONSENSUS/65%    p+hhc.s.chl.hhpuhhhuhhshhs......h.s.h.hh........shphhs..hhhh
CONSENSUS/50%    pKhpEsut+hlaalpuhlsulhslhsps...hhpcsppha.t.....hPtpshssttphh


CLN8_Hs          ITTATGFFCFENVAVH-LSNLIFRTF----------------------------------
CONSENSUS/80%    hhhthuaah..hh.hh...phh......................................
CONSENSUS/65%    hhhphuaahhslhthh...chht.....................................
CONSENSUS/50%    YhhslGYalaslhslh.hpcl++p-...................................


CLN8_Hs          ------------------------DLFLVIHHLFAFLGFLGCLVNLQAGHYLAM--TTLL
CONSENSUS/80%    .........................h..hhHHhhshhhhhhshh..h.hhh.h...hhhl
CONSENSUS/65%    ........................hh.hlhHHhhslhhhshuhhhshhthssh...lhhl
CONSENSUS/50%    ........................hhphllHHllolhllshuassshspsGsl...lllL


CLN8_Hs          LEMSTPFTCVSWMLLKAG----------WSESLFWKLNQWLMIHMFHCRMVLTYHMWWVC
CONSENSUS/80%    h-hss.hhphthhh.h.t..............hh.h.hhhhhh.ahhhRhhhh.hhhhh.
CONSENSUS/65%    t-hoshhlphtphhphts............pthhphhhhhhhhsahhsRlhhhshhhhhs
CONSENSUS/50%    a-sS-saLcls+llpass...........hpphsssshllaslsFllsRLlhhsahllps


CLN8_Hs          FWHWDGLVSSL-------------------------------YLPHLTLFLVGLALLTLI
CONSENSUS/80%    hh..............................................hhh.hhhhhh.h
CONSENSUS/65%    hhhhshhh......................................hhhhhhshhhhLth
CONSENSUS/50%    shthsththt..................................hhhhhhhssllhsLtl


CLN8_Hs          INPYWTHKKTQQLLNPVD
CONSENSUS/80%    hphhWhhhhhphhhh.h.
CONSENSUS/65%    hplhWhhhhhphhhphhp
CONSENSUS/50%    lplaWhhhll+hst+tlp

The grouping of amino acids to classes and class abbreviation (the key) used within consensus sequences are shown below:

ClassKeyResidues
alcoholoS,T
aliphaticlI,L,V
any.A,C,D,E,F,G,H,I,K,L,M,N,P,Q,R,S,T,V,W,Y
aromaticaF,H,W,Y
chargedcD,E,H,K,R
hydrophobichA,C,F,G,H,I,K,L,M,R,T,V,W,Y
negative-D,E
polarpC,D,E,H,K,N,Q,R,S,T
positive+H,K,R
smallsA,C,D,G,N,P,S,T,V
tinyuA,G,S
turnliketA,C,D,E,G,H,K,N,Q,R,S,T