Domains within Rattus norvegicus protein A0A140UHY3_RAT (A0A140UHY3)

EWS RNA-binding protein 1

Alternative representations: 1 /

Protein length661 aa
Source databaseUniProt
Identifiers A0A140UHY3_RAT, A0A140UHY3, ENSRNOP00000069920.1, ENSRNOP00000069920, ENSRNOP00000054193.4, ENSRNOP00000054193, A0A0G2JWK8
Source gene ENSRNOG00000009437
Alternative splicing A0A140UHY3_RAT, B1WC50_RAT

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of Eukaryota

Predicted functional partners

A0A140UHY3_RAT is shown as LOC100912481 in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for LOC100912481

Protein A0A140UHY3_RAT is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map05202Transcriptional misregulation in cancer

KEGG orthologous groups

KONameDescription
K13098TLS, FUSRNA-binding protein FUS
K13209EWSR1RNA-binding protein EWS

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 10116.ENSRNOP00000054193 in eggNOG.

OGTaxonomic classDescription
LKOG1995All organisms (root)RNA-binding protein FUS,RNA-binding protein EWS,transcription initiation factor TFIID subunit 15
KOG1995Eukaryota (superkingdom)RNA-binding protein FUS,RNA-binding protein EWS,transcription initiation factor TFIID subunit 15
HW3ZIMetazoa (kingdom)RNA-binding protein FUS,RNA-binding protein EWS,transcription initiation factor TFIID subunit 15
93M3KChordata (phylum)RNA-binding protein EWS
5QE8HSarcopterygii (superclass)RNA-binding protein EWS
8ZM4AMammalia (class)RNA-binding protein EWS
4RIW4Euarchontoglires (superorder)RNA-binding protein EWS
AI3D5Rodentia (order)RNA-binding protein EWS
8DN9AMyomorpha (suborder)RNA-binding protein EWS
9G515Vertebrata (clade)RNA-binding protein EWS
7HZJYOpisthokonta (clade)RNA-binding protein FUS,RNA-binding protein EWS,transcription initiation factor TFIID subunit 15
H5F5FBilateria (clade)RNA-binding protein FUS,RNA-binding protein EWS,transcription initiation factor TFIID subunit 15
CQ904Muridae (family)RNA-binding protein EWS
ADXDFMurinae (subfamily)RNA-binding protein EWS

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: