Domains within Rattus norvegicus protein B2RYA8_RAT (B2RYA8)

DnaJ heat shock protein family (Hsp40) member B2

Alternative representations: 1 /

Protein length277 aa
Source databaseUniProt
Identifiers B2RYA8_RAT, B2RYA8, ENSRNOP00000074369.1, ENSRNOP00000074369
Source gene ENSRNOG00000019506
Alternative splicing D4ABC2_RAT, B2RYA8_RAT

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of Chordata

Predicted functional partners

B2RYA8_RAT is shown as Dnajb2 in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for Dnajb2

Protein B2RYA8_RAT is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map04141Protein processing in endoplasmic reticulum

KEGG orthologous groups

KONameDescription
K03686dnaJmolecular chaperone DnaJ
K09510DNAJB4DnaJ homolog subfamily B member 4
K09512DNAJB6DnaJ homolog subfamily B member 6
K09508DNAJB2DnaJ homolog subfamily B member 2

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 10116.ENSRNOP00000074369 in eggNOG.

OGTaxonomic classDescription
LCOG0484All organisms (root)molecular chaperone DnaJ,curved DNA-binding protein,DnaJ homolog subfamily B member 4
KOG0714Eukaryota (superkingdom)DnaJ homolog subfamily B member 4,DnaJ homolog subfamily B member 12,DnaJ homolog subfamily B member 13
HSQ1MMetazoa (kingdom)DnaJ homolog subfamily B member 6,DnaJ homolog subfamily B member 2,DnaJ homolog subfamily B member 8
94T3ZChordata (phylum)DnaJ homolog subfamily B member 6,DnaJ homolog subfamily B member 2,DnaJ homolog subfamily B member 8
5QC45Sarcopterygii (superclass)DnaJ homolog subfamily B member 2
8ZJ6AMammalia (class)DnaJ homolog subfamily B member 2
4RR8FEuarchontoglires (superorder)DnaJ homolog subfamily B member 2
AIBMJRodentia (order)DnaJ homolog subfamily B member 2
8D63VMyomorpha (suborder)DnaJ homolog subfamily B member 2
9GQENVertebrata (clade)DnaJ homolog subfamily B member 6,DnaJ homolog subfamily B member 2,DnaJ homolog subfamily B member 8
H3K7MBilateria (clade)DnaJ homolog subfamily B member 6,DnaJ homolog subfamily B member 2,DnaJ homolog subfamily B member 8
7P1PPOpisthokonta (clade)DnaJ homolog subfamily B member 6,DnaJ homolog subfamily B member 2,DnaJ homolog subfamily B member 8
CQ4EMMuridae (family)DnaJ homolog subfamily B member 2
AEATRMurinae (subfamily)DnaJ homolog subfamily B member 2

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: