Domains within Mus musculus protein CLH1_MOUSE (Q68FD5)

Clathrin heavy chain 1

Alternative representations: 1 /

Protein length1675 aa
Source databaseUniProt
Identifiers CLH1_MOUSE, Q68FD5, ENSMUSP00000099475.4, ENSMUSP00000099475
Source gene ENSMUSG00000047126
Alternative splicing CLH1_MOUSE, Q5SXR6_MOUSE, F6Z1R4_MOUSE

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of Eukaryota

Predicted functional partners

CLH1_MOUSE is shown as Cltc in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for Cltc

Protein CLH1_MOUSE is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map05016Huntington disease

KEGG orthologous groups

KONameDescription
K04646CLTCclathrin heavy chain

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 10090.ENSMUSP00000099475 in eggNOG.

OGTaxonomic classDescription
LKOG0985All organisms (root)clathrin heavy chain,solute carrier family 25 (mitochondrial citrate transporter), member 1
KOG0985Eukaryota (superkingdom)clathrin heavy chain,solute carrier family 25 (mitochondrial citrate transporter), member 1
HU6GQMetazoa (kingdom)clathrin heavy chain,solute carrier family 25 (mitochondrial citrate transporter), member 1
94UX2Chordata (phylum)clathrin heavy chain,solute carrier family 25 (mitochondrial citrate transporter), member 1
5RAECSarcopterygii (superclass)clathrin heavy chain,solute carrier family 25 (mitochondrial citrate transporter), member 1
8ZH7UMammalia (class)clathrin heavy chain,solute carrier family 25 (mitochondrial citrate transporter), member 1
4RHR5Euarchontoglires (superorder)clathrin heavy chain,solute carrier family 25 (mitochondrial citrate transporter), member 1
AI4CJRodentia (order)clathrin heavy chain
8D9H9Myomorpha (suborder)clathrin heavy chain
9G2JYVertebrata (clade)clathrin heavy chain,solute carrier family 25 (mitochondrial citrate transporter), member 1
H3ZWMBilateria (clade)clathrin heavy chain,solute carrier family 25 (mitochondrial citrate transporter), member 1
7M5SIOpisthokonta (clade)clathrin heavy chain,solute carrier family 25 (mitochondrial citrate transporter), member 1
CQF1EMuridae (family)clathrin heavy chain
AE1NTMurinae (subfamily)clathrin heavy chain
5PQQPMus (genus)clathrin heavy chain
HE0B6Mus (subgenus)clathrin heavy chain

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: