Domains within Homo sapiens protein E9PG19_HUMAN (E9PG19)

F-BAR and double SH3 domains protein 2

Alternative representations: 1 /

Protein length764 aa
Source databaseUniProt
Identifiers E9PG19_HUMAN, E9PG19, ENSP00000386987.1, ENSP00000386987, A0A2I3TUA1_PANTR, A0A2I3TUA1, C9JM66_HUMAN, C9JM66, A0A2J8PZK8_PANTR, A0A2J8PZK8, E7ENZ2_HUMAN, E7ENZ2, A0A2I3RSI9_PANTR, A0A2I3RSI9
Source gene ENSG00000137478
Alternative splicing A0A024R5H2_HUMAN, E9PG19_HUMAN, FCSD2_HUMAN, B8ZZW8_HUMAN, ENSP00000402972.2, ENSP00000386314.1, H0Y6M2_HUMAN, H0YG35_HUMAN, ENSP00000408706.1

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of cellular organisms

Predicted functional partners

E9PG19_HUMAN is shown as FCHSD2 in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for FCHSD2

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 9598.ENSPTRP00000092806 in eggNOG.

OGTaxonomic classDescription
LKOG3565All organisms (root)SLIT-ROBO Rho GTPase activating protein,formin-binding protein 1,F-BAR and double SH3 domains protein
KOG3565Eukaryota (superkingdom)SLIT-ROBO Rho GTPase activating protein,formin-binding protein 1,F-BAR and double SH3 domains protein
HT6VVMetazoa (kingdom)F-BAR and double SH3 domains protein
94B04Chordata (phylum)F-BAR and double SH3 domains protein
5QGZVSarcopterygii (superclass)F-BAR and double SH3 domains protein
8Z97DMammalia (class)F-BAR and double SH3 domains protein
4R2VWEuarchontoglires (superorder)F-BAR and double SH3 domains protein
4ZV6QPrimates (order)F-BAR and double SH3 domains protein
98PFQHaplorrhini (suborder)F-BAR and double SH3 domains protein
BV290Simiiformes (infraorder)F-BAR and double SH3 domains protein
9EVP4Catarrhini (parvorder)F-BAR and double SH3 domains protein
9GGRAVertebrata (clade)F-BAR and double SH3 domains protein
H3TBBBilateria (clade)F-BAR and double SH3 domains protein
7MG37Opisthokonta (clade)F-BAR and double SH3 domains protein
FX5M9Hominoidea (superfamily)F-BAR and double SH3 domains protein
5N1AIHominidae (family)F-BAR and double SH3 domains protein
5XS1XHomininae (subfamily)F-BAR and double SH3 domains protein

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: