Domains within Homo sapiens protein ENSP00000369440.3

Alternative representations: 1 /

Protein length516 aa
Source databaseEnsembl
Identifiers ENSP00000369440.3, ENSP00000369440
Source gene ENSG00000121236
Alternative splicing TRIM6_HUMAN, ENSP00000414108.1, ENSP00000427704.1, E9PFM0_HUMAN, ENSP00000369440.3

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of Euteleostomi

Predicted functional partners

ENSP00000369440.3 is shown as TRIM6 in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for TRIM6

Protein ENSP00000369440.3 is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map04361Axon regeneration
map04120Ubiquitin mediated proteolysis
map05170Human immunodeficiency virus 1 infection

KEGG orthologous groups

KONameDescription
K06712BTN, CD277butyrophilin
K11999TRIM6_22_34tripartite motif-containing protein 6/22/34

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 9606.ENSP00000369440 in eggNOG.

OGTaxonomic classDescription
LKOG2177All organisms (root)butyrophilin,tripartite motif-containing protein 2/3,deltex [EC:2.3.2.27]
KOG2177Eukaryota (superkingdom)butyrophilin,tripartite motif-containing protein 2/3,deltex [EC:2.3.2.27]
HVPGDMetazoa (kingdom)butyrophilin,tripartite motif-containing protein 35,tripartite motif-containing protein 2/3
93UB5Chordata (phylum)tripartite motif-containing protein 6/22/34,tripartite motif-containing protein 5 [EC:2.3.2.27],tripartite motif family-like protein 1
5QHQPSarcopterygii (superclass)tripartite motif-containing protein 6/22/34,tripartite motif-containing protein 5 [EC:2.3.2.27],tripartite motif family-like protein 1
8ZHKKMammalia (class)tripartite motif-containing protein 6/22/34,tripartite motif-containing protein 5 [EC:2.3.2.27],tripartite motif family-like protein 1
4R42DEuarchontoglires (superorder)tripartite motif-containing protein 6/22/34
4ZQENPrimates (order)tripartite motif-containing protein 6/22/34
98KN2Haplorrhini (suborder)tripartite motif-containing protein 6/22/34
BV8GQSimiiformes (infraorder)tripartite motif-containing protein 6/22/34
9ESS4Catarrhini (parvorder)tripartite motif-containing protein 6/22/34
H3JGEBilateria (clade)tripartite motif-containing protein 6/22/34,tripartite motif-containing protein 5 [EC:2.3.2.27],tripartite motif family-like protein 1
9FWKFVertebrata (clade)tripartite motif-containing protein 6/22/34,tripartite motif-containing protein 5 [EC:2.3.2.27],tripartite motif family-like protein 1
7KUB7Opisthokonta (clade)butyrophilin,tripartite motif-containing protein 35,tripartite motif-containing protein 2/3
FX1BGHominoidea (superfamily)tripartite motif-containing protein 6/22/34
5NDR5Hominidae (family)tripartite motif-containing protein 6/22/34
5XV4IHomininae (subfamily)tripartite motif-containing protein 6/22/34

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: