Domains within Homo sapiens protein ENSP00000428714.1

Alternative representations: 1 /

Protein length1278 aa
Source databaseEnsembl
Identifiers ENSP00000428714.1, ENSP00000428714
Source gene ENSG00000105339
Alternative splicing ENSP00000430625.1, E5RIR7_HUMAN, E5RH95_HUMAN, ENSP00000428714.1, E5RHH2_HUMAN, E5RI43_HUMAN, ENSP00000428276.1, H0YAW2_HUMAN, H0YBH5_HUMAN, ENSP00000430912.1, H0YBK9_HUMAN, DEND3_HUMAN, A2RUS2-2

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

Predicted functional partners

ENSP00000428714.1 is shown as DENND3 in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for DENND3

Protein ENSP00000428714.1 is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map05166Human T-cell leukemia virus 1 infection

KEGG orthologous groups

KONameDescription
K20163DENND4DENN domain-containing protein 4

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 9606.ENSP00000428714 in eggNOG.

OGTaxonomic classDescription
LKOG2127All organisms (root)DENN domain-containing protein 4,DENN domain-containing protein 3,WD repeat-containing protein 54
KOG2127Eukaryota (superkingdom)DENN domain-containing protein 4,DENN domain-containing protein 3,WD repeat-containing protein 54
HTDGNMetazoa (kingdom)DENN domain-containing protein 3
94BU1Chordata (phylum)DENN domain-containing protein 3
5QEN8Sarcopterygii (superclass)DENN domain-containing protein 3
8Z9D0Mammalia (class)DENN domain-containing protein 3
4RGYSEuarchontoglires (superorder)DENN domain-containing protein 3
500GAPrimates (order)DENN domain-containing protein 3
98RP7Haplorrhini (suborder)DENN domain-containing protein 3
BV4F2Simiiformes (infraorder)DENN domain-containing protein 3
9EP8UCatarrhini (parvorder)DENN domain-containing protein 3
H63AGBilateria (clade)DENN domain-containing protein 3
7JREROpisthokonta (clade)DENN domain-containing protein 3
9GT31Vertebrata (clade)DENN domain-containing protein 3
FXBZAHominoidea (superfamily)DENN domain-containing protein 3
5N1ANHominidae (family)DENN domain-containing protein 3
5XVB6Homininae (subfamily)DENN domain-containing protein 3

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: