Domains within Homo sapiens protein O75564-2

Isoform 2 of Jerky protein homolog

Alternative representations: 1 /

Protein length568 aa
Source databaseUniProt
Identifiers O75564-2, ENSP00000485390.1, ENSP00000485390, ENSP00000482410.1, ENSP00000482410
Source gene ENSG00000234616
Alternative splicing O75564-2, JERKY_HUMAN, ENSP00000482585.1

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

Predicted functional partners

O75564-2 is shown as JRK in the network

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The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for JRK

Protein O75564-2 is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map05168Herpes simplex virus 1 infection

KEGG orthologous groups

KONameDescription
K09228KRABKRAB domain-containing zinc finger protein
K11496CENPBcentromere protein B
K22594POGZpogo transposable element with ZNF domain

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 9606.ENSP00000482410 in eggNOG.

OGTaxonomic classDescription
LKOG3105All organisms (root)pogo transposable element with ZNF domain,centromere protein B,high-mobility group nucleosome-binding domain-containing protein 1
KOG3105Eukaryota (superkingdom)pogo transposable element with ZNF domain,centromere protein B,high-mobility group nucleosome-binding domain-containing protein 1
HVNP8Metazoa (kingdom)centromere protein B,DnaJ homolog subfamily B member 12,KRAB domain-containing zinc finger protein
93KUIChordata (phylum)DDE_1,HTH_Tnp_Tc5,CENP-B_N
5R9Q5Sarcopterygii (superclass)HTH_Tnp_Tc5,CENP-B_N,DDE_1
8ZNYGMammalia (class)CENP-B_N,HTH_Tnp_Tc5,DDE_1
4R2F0Euarchontoglires (superorder)CENP-B_N,HTH_Tnp_Tc5,DDE_1
4ZP3CPrimates (order)CENP-B_N,HTH_Tnp_Tc5,DDE_1
98G1KHaplorrhini (suborder)CENP-B_N,HTH_Tnp_Tc5,DDE_1
BVHIASimiiformes (infraorder)CENP-B_N,HTH_Tnp_Tc5,DDE_1
9EVJCCatarrhini (parvorder)CENP-B_N,HTH_Tnp_Tc5,DDE_1
7KZ6XOpisthokonta (clade)centromere protein B,DnaJ homolog subfamily B member 12,KRAB domain-containing zinc finger protein
H5EU2Bilateria (clade)DnaJ homolog subfamily B member 12,KRAB domain-containing zinc finger protein,nesprin-1
9FI7PVertebrata (clade)DDE_1,HTH_Tnp_Tc5,CENP-B_N
FWZPKHominoidea (superfamily)CENP-B_N,HTH_Tnp_Tc5,DDE_1
5NCRYHominidae (family)CENP-B_N,HTH_Tnp_Tc5,DDE_1
5XVZUHomininae (subfamily)CENP-B_N,HTH_Tnp_Tc5,DDE_1

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: