Domains within Mus musculus protein PPARD_MOUSE (P35396)

Peroxisome proliferator-activated receptor delta

Alternative representations: 1 /

Protein length440 aa
Source databaseUniProt
Identifiers PPARD_MOUSE, P35396, ENSMUSP00000002320.8, ENSMUSP00000002320, P37239, Q546I3_MOUSE, Q546I3, E9PV57_MOUSE, E9PV57
Source gene ENSMUSG00000002250
Alternative splicing PPARD_MOUSE, ENSMUSP00000133077.1

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of Metazoa

Predicted functional partners

PPARD_MOUSE is shown as Ppard in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for Ppard

Protein PPARD_MOUSE is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map05221Acute myeloid leukemia
map05200Pathways in cancer

KEGG orthologous groups

KONameDescription
K08554NR3B3, ESRRGestrogen-related receptor gamma
K04504NR1C2, PPARDperoxisome proliferator-activated receptor delta

Post-translational modifications

PTM annotation is taken from PTMcode, a resource of known and predicted functional associations between protein post-translational modifications (PTMs). There are 4 PTMs annotated in this protein:

PTMCount
Phosphorylation3
Methylation1

To see the full details, including possible functional associations between the PTMs, please visit the PTMcode annotation page for protein Ppard.

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 10090.ENSMUSP00000002320 in eggNOG.

OGTaxonomic classDescription
LKOG3575All organisms (root)estrogen-related receptor gamma,nuclear receptor subfamily 2 group E member 3,retinoid X receptor alpha
KOG3575Eukaryota (superkingdom)estrogen-related receptor gamma,nuclear receptor subfamily 2 group E member 3,retinoid X receptor alpha
HV00AMetazoa (kingdom)peroxisome proliferator-activated receptor delta,nuclear receptor subfamily 1 group D member 1
94CDSChordata (phylum)peroxisome proliferator-activated receptor delta
5QB60Sarcopterygii (superclass)peroxisome proliferator-activated receptor delta
8Z0CWMammalia (class)peroxisome proliferator-activated receptor delta
4RF7NEuarchontoglires (superorder)peroxisome proliferator-activated receptor delta
AI5KVRodentia (order)peroxisome proliferator-activated receptor delta
8D7XTMyomorpha (suborder)peroxisome proliferator-activated receptor delta
7I94WOpisthokonta (clade)peroxisome proliferator-activated receptor delta,nuclear receptor subfamily 1 group D member 1
9G573Vertebrata (clade)peroxisome proliferator-activated receptor delta
H3MWJBilateria (clade)peroxisome proliferator-activated receptor delta,nuclear receptor subfamily 1 group D member 1
CQ3H2Muridae (family)peroxisome proliferator-activated receptor delta
AE2FAMurinae (subfamily)peroxisome proliferator-activated receptor delta
5PHSKMus (genus)peroxisome proliferator-activated receptor delta
HE78SMus (subgenus)peroxisome proliferator-activated receptor delta

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: