Domains within Homo sapiens protein Q58F21-3

Isoform 3 of Bromodomain testis-specific protein

Alternative representations: 1 /

Protein length951 aa
Source databaseUniProt
Identifiers Q58F21-3, ENSP00000387822.2, ENSP00000387822
Source gene ENSG00000137948
Alternative splicing BRDT_HUMAN, ENSP00000359416.2, ENSP00000396351.1, ENSP00000416714.1, ENSP00000408625.1, ENSP00000400002.1, ENSP00000400199.1, ENSP00000404969.1, ENSP00000414349.1, ENSP00000447394.1, ENSP00000446599.1, C9JQ27_HUMAN, Q58F21-4, Q58F21-3

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of Fungi/Metazoa group

Predicted functional partners

Q58F21-3 is shown as BRDT in the network

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The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for BRDT

Protein Q58F21-3 is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map03008Ribosome biogenesis in eukaryotes
map05225Hepatocellular carcinoma

KEGG orthologous groups

KONameDescription
K11721BRD3bromodomain-containing protein 3

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 9606.ENSP00000387822 in eggNOG.

OGTaxonomic classDescription
LKOG1474All organisms (root)bromodomain-containing protein 3,bromodomain-containing protein 4,bromodomain-containing protein 2
KOG1474Eukaryota (superkingdom)bromodomain-containing protein 3,bromodomain-containing protein 4,bromodomain-containing protein 2
HSZJXMetazoa (kingdom)bromodomain-containing protein 3,bromodomain-containing protein 2,bromodomain-containing protein 4
93X2CChordata (phylum)bromodomain-containing protein 3,bromodomain-containing protein 2,bromodomain-containing protein 4
5R1GUSarcopterygii (superclass)bromodomain-containing protein 3,bromodomain testis-specific protein,bromodomain-containing protein 4
8ZK3EMammalia (class)bromodomain testis-specific protein
4RE41Euarchontoglires (superorder)bromodomain testis-specific protein
4ZTZ4Primates (order)bromodomain testis-specific protein
98PFSHaplorrhini (suborder)bromodomain testis-specific protein
BVGEXSimiiformes (infraorder)bromodomain testis-specific protein
9ES3WCatarrhini (parvorder)bromodomain testis-specific protein
9FA6QVertebrata (clade)bromodomain-containing protein 3,bromodomain-containing protein 2,bromodomain-containing protein 4
H3EENBilateria (clade)bromodomain-containing protein 3,bromodomain-containing protein 2,bromodomain-containing protein 4
7JZ6WOpisthokonta (clade)bromodomain-containing protein 3,bromodomain-containing protein 2,bromodomain-containing protein 4
FX3UTHominoidea (superfamily)bromodomain testis-specific protein
5N9MAHominidae (family)bromodomain testis-specific protein
5Y3I6Homininae (subfamily)bromodomain testis-specific protein

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: