Letunic et al. (2017) Nucleic Acids Res doi: 10.1093/nar/gkx922
Letunic et al. (2020) Nucleic Acids Res doi: 10.1093/nar/gkaa937

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Select your default SMART mode

You can use SMART in two different modes: normal or genomic.The main difference is in the underlying protein database used. In Normal SMART, the database contains Swiss-Prot, SP-TrEMBL and stable Ensembl proteomes. In Genomic SMART, only the proteomes of completely sequenced genomes are used; Ensembl for metazoans and Swiss-Prot for the rest. The complete list of genomes in Genomic SMART is available here.

The protein database in Normal SMART has significant redundancy, even though identical proteins are removed. If you use SMART to explore domain architectures, or want to find exact domain counts in various genomes, consider switching to Genomic mode. The numbers in the domain annotation pages will be more accurate, and there will not be many protein fragments corresponding to the same gene in the architecture query results. Remember you are exploring a limited set of genomes, though.

Different color schemes are used to easily identify the mode you're in.

Normal mode	Genomic mode

Click on the images above to select your default mode.

Information about your selected mode is stored in a browser cookie. If you for whatever reason don't want/can't use cookies, access SMART through this page.

You can easily change modes later, by clicking on the links in the 'SMART MODE' header box, or in your personal preference settings ('SETUP' link in the menu):