Overview
SMART (a Simple Modular Architecture Research Tool) allows the identification and annotation of genetically mobile domains and the analysis of domain architectures. More than 1400 domain families found in signalling, extracellular and chromatin-associated proteins are detectable. These domains are extensively annotated with respect to phyletic distributions, functional class, tertiary structures and functionally important residues. Each domain found in a non-redundant protein database as well as search parameters and taxonomic information are stored in a relational database system. Web user interface to this database allow searches for proteins containing specific combinations of domains in defined taxa. For all the details, please refer to the publications on SMART, listed below.
SMART Publications
- Letunic I and Bork P SMART: recent updates, new developments and status in 2020 (2020) Nucleic Acids Res; doi:10.1093/nar/gkaa937
- Letunic I and Bork P 20 years of the SMART protein domain annotation resource (2017) Nucleic Acids Res; doi:10.1093/nar/gkx922
- Letunic I, Doerks T, Bork P SMART: recent updates, new developments and status in 2015 (2014) Nucleic Acids Res; doi:10.1093/nar/gku949
- Letunic I, Doerks T, Bork P SMART 7: recent updates to the protein domain annotation resource (2012) Nucleic Acids Res; doi:10.1093/nar/gkr931
- Letunic I, Doerks T, Bork P SMART 6: recent updates and new developments. (2008) Nucleic Acids Res; doi:10.1093/nar/gkn808
- Letunic I et al. SMART 5: domains in the context of genomes and networks. (2006) Nucleic Acids Res; doi: 10.1093/nar/gkj079
- Letunic I et al. SMART 4.0: towards genomic data integration. (2004) Nucleic Acids Res; doi: 10.1093/nar/gkh088
- Letunic I et al. Recent improvements to the SMART domain-based sequence annotation resource. (2002) Nucleic Acids Res; doi: 10.1093/nar/30.1.242
- Schultz, J. et al. SMART: A Web-based tool for the study of genetically mobile domains. (2000) Nucleic Acids Res; doi: 10.1093/nar/28.1.231
- Copley, R.R. et al. Protein families in multicellular organisms. (1999) Curr Opin Struct Biol; doi: 10.1016/S0959-440X(99)80055-4
- Ponting, C.P. et al. SMART: identification and annotation of domains from signalling and extracellular protein sequences. (1999) Nucleic Acids Res; doi: 10.1093/nar/27.1.229
- Schultz, J. et al. SMART, a simple modular architecture research tool: Identification of signaling domains. (1998) PNAS; doi: 10.1073/pnas.95.11.5857
Usage terms and licensing
- All protein images generated by SMART are licensed under: CC BY-SA 4.0
- SMART usage terms and conditions
- SMART data (Hidden Markov Models, alignments and thresholds) are available via a license. The license is free to academics, but not commercial users. For further details on the academic license, visit the SMART page at EMBLEM. If you are a non-acadmic user, please contact biobyte solutions GmbH.
Feedback
In creating SMART, we have tried to make it user-friendly, information-rich and relatively error-free. However, we encourage everyone who:
- has trouble in understanding the SMART output pages,
- wishes to add to (or criticise!) the annotation of domain families,
- has suggestions of domains presently not included among the SMART set,
to contact us via e-mail. You can also help us by filling the de.NBI user survey about the SMART service.