 AIF_CApoptosis-inducing factor, mitochondrion-associated, C-term | |
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| SMART ACC: | SM001353 |
| Description: | This C-terminal domain appears to be a dimerization domain of the mitochondrial apoptosis-inducing factor 1. protein. The domain also appears at the C-terminus of FAD-dependent pyridine nucleotide-disulfide oxidoreductases. Apoptosis inducing factor (AIF) is a bifunctional mitochondrial flavoprotein critical for energy metabolism and induction of caspase-independent apoptosis. On reduction with NADH, AIF undergoes dimerization and forms tight, long-lived FADH2-NAD charge-transfer complexes proposed to be functionally important. |
| Family alignment: | View the Family alignment or the Alignment consensus sequence |
| There are 1 222 AIF_C domains in 1 220 proteins in SMART's NRDB database. | |
Taxonomic distribution of proteins containing AIF_C domains
The tree below includes only several representative species and genera. The complete taxonomic breakdown of all proteins containing AIF_C domains can be accessed here. Click the counts or percentage values to display the corresponding proteins.
Predicted cellular role
| Cellular role: | Signalling |
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Relevant references for this domain
Primary literature for the AIF_C domain is listed below. Automatically-derived, secondary literature is also available.
KEGG pathways involving proteins which contain this domain
This information is based on the mapping of SMART genomic protein database to KEGG orthologous groups. Percentages are related to the number of proteins containing a AIF_C domain which could be assigned to a KEGG orthologous group, and not all proteins containing AIF_C domains. Please note that proteins can be included in multiple pathways, ie. the numbers below will not add to 100%.
KEGG pathways
KEGG orthologous groups
3D structures in PDB containing this domain
Links to other resources describing this domain
| Pfam | AIF_C |
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