 AIP3Actin interacting protein 3 | |
|---|---|
| SMART ACC: | SM000806 |
| Description: | Aip3p/Bud6p is a regulator of cell and cytoskeletal polarity in Saccharomyces cerevisiae that was previously identified as an actin-interacting protein. Actin-interacting protein 3 (Aip3p) localizes at the cell cortex where cytoskeleton assembly must be achieved to execute polarized cell growth, and deletion of AIP3 causes gross defects in cell and cytoskeletal polarity. Aip3p localization is mediated by the secretory pathway, mutations in early- or late-acting components of the secretory apparatus lead to Aip3p mislocalization (PUBMED:10679021). |
| InterPro ACC: | IPR005613 |
| InterPro abstract: | This entry represents the C-terminal domain of actin interacting protein 3 (also known as Bud6 in budding yeasts). Bud6 is an actin-and formin-interacting protein. The N-terminal half of Bud6 is a microtubule binding domain required for its localisation and for its function in cortical capture of astral microtubule ends. The C-terminal half (residues 489-788) directly facilitates actin filament … expand |
| GO function: | cytoskeletal regulatory protein binding (GO:0005519) |
| Family alignment: | View the Family alignment or the Alignment consensus sequence |
| There are 637 AIP3 domains in 637 proteins in SMART's NRDB database. | |
Taxonomic distribution of proteins containing AIP3 domains
The tree below includes only several representative species and genera. The complete taxonomic breakdown of all proteins containing AIP3 domains can be accessed here. Click the counts or percentage values to display the corresponding proteins.
Predicted cellular role
| Cellular role: | Interaction (with the environment) |
|---|
Relevant references for this domain
Primary literature for the AIP3 domain is listed below. Automatically-derived, secondary literature is also available.
KEGG pathways involving proteins which contain this domain
This information is based on the mapping of SMART genomic protein database to KEGG orthologous groups. Percentages are related to the number of proteins containing a AIP3 domain which could be assigned to a KEGG orthologous group, and not all proteins containing AIP3 domains. Please note that proteins can be included in multiple pathways, ie. the numbers below will not add to 100%.