 AIRCAIR carboxylase | |
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| SMART ACC: | SM001001 |
| Description: | Members of this family catalyse the decarboxylation of 1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR). This family catalyse the sixth step of de novo purine biosynthesis. Some members of this family contain two copies of this domain. |
| InterPro ACC: | IPR000031 |
| InterPro abstract: | The novo purine biosynthesis proceeds by two divergent paths. In bacteria, yeasts, and plants, 5-aminoimidazole ribonucleotide (AIR) is converted to 4-carboxy-AIR (CAIR) by two enzymes: N5-carboxy-AIR (N5-CAIR) synthetase (PurK) and N5-CAIR mutase (class I PurE). In animals, the conversion of AIR to CAIR requires a single enzyme, AIR carboxylase (class II PurE) [ PUBMED:7918411 … expand |
| GO process: | 'de novo' IMP biosynthetic process (GO:0006189) |
| Family alignment: | View the Family alignment or the Alignment consensus sequence |
| There are 23 473 AIRC domains in 23 424 proteins in SMART's NRDB database. | |
Taxonomic distribution of proteins containing AIRC domains
The tree below includes only several representative species and genera. The complete taxonomic breakdown of all proteins containing AIRC domains can be accessed here. Click the counts or percentage values to display the corresponding proteins.
Predicted cellular role
| Cellular role: | Metabolic |
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Relevant references for this domain
Primary literature for the AIRC domain is listed below. Automatically-derived, secondary literature is also available.
KEGG pathways involving proteins which contain this domain
This information is based on the mapping of SMART genomic protein database to KEGG orthologous groups. Percentages are related to the number of proteins containing a AIRC domain which could be assigned to a KEGG orthologous group, and not all proteins containing AIRC domains. Please note that proteins can be included in multiple pathways, ie. the numbers below will not add to 100%.