 AKAP_110A-kinase anchor protein 110 kDa | |
|---|---|
| SMART ACC: | SM000807 |
| Description: | This family consists of several mammalian protein kinase A anchoring protein 3 (PRKA3) or A-kinase anchor protein 110 kDa (AKAP 110) sequences. Agents that increase intracellular cAMP are potent stimulators of sperm motility. Anchoring inhibitor peptides, designed to disrupt the interaction of the cAMP-dependent protein kinase A (PKA) with A kinase-anchoring proteins (AKAPs), are potent inhibitors of sperm motility. PKA anchoring is a key biochemical mechanism controlling motility. AKAP110 shares compartments with both RI and RII isoforms of PKA and may function as a regulator of both motility- and head-associated functions such as capacitation and the acrosome reaction (PUBMED:10319321). |
| InterPro ACC: | IPR020799 |
| InterPro abstract: | This family consists of several mammalian protein kinase A anchoring protein 3 (PRKA3) or A-kinase anchor protein 110kDa (AKAP 110) sequences. Agents that increase intracellular cAMP are potent stimulators of sperm motility. Anchoring inhibitor peptides, designed to disrupt the interaction of the cAMP-dependent protein kinase A (PKA) with A kinase-anchoring proteins (AKAPs), are potent inhibitors … expand |
| Family alignment: | View the Family alignment or the Alignment consensus sequence |
| There are 302 AKAP_110 domains in 301 proteins in SMART's NRDB database. | |
Taxonomic distribution of proteins containing AKAP_110 domains
The tree below includes only several representative species and genera. The complete taxonomic breakdown of all proteins containing AKAP_110 domains can be accessed here. Click the counts or percentage values to display the corresponding proteins.
Predicted cellular role
| Cellular role: | Replication |
|---|
Relevant references for this domain
Primary literature for the AKAP_110 domain is listed below. Automatically-derived, secondary literature is also available.