 APC2Anaphase promoting complex (APC) subunit 2 | |
|---|---|
| SMART ACC: | SM001013 |
| Description: | The anaphase promoting complex or cyclosome (APC2) is an E3 ubiquitin ligase which is part of the SCF family of ubiquitin ligases. Ubiquitin ligases catalyse the transfer of ubiquitin from the ubiquitin conjugating enzyme (E2), to the substrate protein. |
| InterPro ACC: | IPR014786 |
| InterPro abstract: | This entry represents a domain found in the C-terminal of APC subunit 2 (ANAPC2). ANAPC2 is part of the catalytic component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle [ PUBMED:11739784 … expand |
| Family alignment: | View the Family alignment or the Alignment consensus sequence |
| There are 1 082 APC2 domains in 1 081 proteins in SMART's NRDB database. | |
Taxonomic distribution of proteins containing APC2 domains
The tree below includes only several representative species and genera. The complete taxonomic breakdown of all proteins containing APC2 domains can be accessed here. Click the counts or percentage values to display the corresponding proteins.
Predicted cellular role
| Cellular role: | Replication |
|---|
Relevant references for this domain
Primary literature for the APC2 domain is listed below. Automatically-derived, secondary literature is also available.
KEGG pathways involving proteins which contain this domain
This information is based on the mapping of SMART genomic protein database to KEGG orthologous groups. Percentages are related to the number of proteins containing a APC2 domain which could be assigned to a KEGG orthologous group, and not all proteins containing APC2 domains. Please note that proteins can be included in multiple pathways, ie. the numbers below will not add to 100%.