Aspzincin_M35 Lysine-specific metallo-endopeptidase
SMART ACC:	SM001351
Description:	This is the catalytic region of aspzincins, a group of lysine-specific metallo-endopeptidases in the M35 family. They exhibit the following active-site architecture. The active site is composed of two helices and a loop region and includes the HExxH and GTxDxxYG motifs. In UniProt:P81054 His117, His121 and Asp130 coordinate to the catalytic zinc ligands. An electrostatically negative region composed of Asp154 and Glu157 attracts a positively charged Lys side chain of a substrate in a specific manner (PMID:11679721).
InterPro ACC:	IPR029463
InterPro abstract:	This is the catalytic domain of aspzincins, a group of lysine-specific metallo-endopeptidases in the MEROPS M35 family. They exhibit the following active-site architecture: the active site is composed of two helices and a loop region and includes the HExxH and GTxDxxYG motifs. In protein P81054 His117, His121 … expand This is the catalytic domain of aspzincins, a group of lysine-specific metallo-endopeptidases in the MEROPS M35 family. They exhibit the following active-site architecture: the active site is composed of two helices and a loop region and includes the HExxH and GTxDxxYG motifs. In protein P81054 His117, His121 and Asp130 coordinate to the catalytic zinc ligands. An electrostatically negative region composed of Asp154 and Glu157 attracts a positively charged Lys side chain of a substrate in a specific manner [ PUBMED:11223512 ]. collapse
GO function:	metalloendopeptidase activity (GO:0004222)
Family alignment:	View the Family alignment or the Alignment consensus sequence
There are 911 Aspzincin_M35 domains in 911 proteins in SMART's NRDB database.

Taxonomic distribution of proteins containing Aspzincin_M35 domains

The tree below includes only several representative species and genera. The complete taxonomic breakdown of all proteins containing Aspzincin_M35 domains can be accessed here. Click the counts or percentage values to display the corresponding proteins.

Relevant references for this domain

Primary literature for the Aspzincin_M35 domain is listed below. Automatically-derived, secondary literature is also available.

KEGG pathways involving proteins which contain this domain

This information is based on the mapping of SMART genomic protein database to KEGG orthologous groups. Percentages are related to the number of proteins containing a Aspzincin_M35 domain which could be assigned to a KEGG orthologous group, and not all proteins containing Aspzincin_M35 domains. Please note that proteins can be included in multiple pathways, ie. the numbers below will not add to 100%.

KEGG pathways

Some of these pathways are included in the interactive Pathways Explorer overview maps. Select an overview map and click the button below to highlight them in iPath.

KEGG orthologous groups

Some of these KOs are included in the interactive Pathways Explorer overview maps. Select an overview map and click the button below to highlight them in iPath.

3D structures in PDB containing this domain

Links to other resources describing this domain

InterPro	IPR029463
Pfam	Aspzincin_M35