 BTBBroad-Complex, Tramtrack and Bric a brac | |
|---|---|
| SMART ACC: | SM000225 |
| Description: | Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures. |
| InterPro ACC: | IPR000210 |
| InterPro abstract: | The BTB domain (Broad-Complex, Tramtrack and Bric a brac) is also known as the POZ domain (POxvirus and Zinc finger). It is a homodimerisation domain occurring at the N terminus of proteins containing multiple copies of either zinc fingers of the C2H2 type or Kelch repeats [ PUBMED:7938017 PUBMED:7958847 … expand |
| GO function: | protein binding (GO:0005515) |
| Family alignment: | View the Family alignment or the Alignment consensus sequence |
| There are 113 741 BTB domains in 107 385 proteins in SMART's NRDB database. | |
Taxonomic distribution of proteins containing BTB domains
The tree below includes only several representative species and genera. The complete taxonomic breakdown of all proteins containing BTB domains can be accessed here. Click the counts or percentage values to display the corresponding proteins.
Relevant references for this domain
Primary literature for the BTB domain is listed below. Automatically-derived, secondary literature is also available.
Disease genes where sequence variants are found in this domain
UniRef sequences and OMIM curated human diseases associated with missense mutations within the BTB domain.
| Protein | Description | Disease / phenotype |
|---|---|---|
| GAN_HUMAN | OMIM:256850 : Giant axonal neuropathy-1 | |
| OMIM:605379 : Giant axonal neuropathy-1 | ||
| OMIM:256850 : no description |
KEGG pathways involving proteins which contain this domain
This information is based on the mapping of SMART genomic protein database to KEGG orthologous groups. Percentages are related to the number of proteins containing a BTB domain which could be assigned to a KEGG orthologous group, and not all proteins containing BTB domains. Please note that proteins can be included in multiple pathways, ie. the numbers below will not add to 100%.