Bac_DnaA_C Bacterial dnaA protein helix-turn-helix domain
SMART ACC:	SM000760
Description:	Could be involved in DNA-binding.
InterPro ACC:	IPR013159
InterPro abstract:	This entry represents the C-terminal domain of bacterial DnaA proteins [ PUBMED:8110826 PUBMED:1779750 PUBMED:2558436 ] that play an important role in initiating and … expand This entry represents the C-terminal domain of bacterial DnaA proteins [ PUBMED:8110826 PUBMED:1779750 PUBMED:2558436 ] that play an important role in initiating and regulating chromosomal replication. DnaA is an ATP- and DNA-binding protein. It binds specifically to 9 bp nucleotide repeats known as dnaA boxes which are found in the chromosome origin of replication (oriC). DnaA is a protein of about 50kDa that contains two conserved regions: the first is located in the N-terminal half and corresponds to the ATP-binding domain, the second is located in the C-terminal half and could be involved in DNA-binding. The protein may also bind the RNA polymerase beta subunit, the dnaB and dnaZ proteins, and the groE gene products (chaperonins) [ PUBMED:2172087 ]. collapse
GO process:	regulation of DNA replication (GO:0006275), DNA replication initiation (GO:0006270)
GO function:	sequence-specific DNA binding (GO:0043565), ATP binding (GO:0005524)
Family alignment:	View the Family alignment or the Alignment consensus sequence
There are 20 751 Bac_DnaA_C domains in 20 737 proteins in SMART's NRDB database.

Taxonomic distribution of proteins containing Bac_DnaA_C domains

The tree below includes only several representative species and genera. The complete taxonomic breakdown of all proteins containing Bac_DnaA_C domains can be accessed here. Click the counts or percentage values to display the corresponding proteins.

Predicted cellular role

Cellular role:	Replication
Binding / catalysis:	DNA

Relevant references for this domain

Primary literature for the Bac_DnaA_C domain is listed below. Automatically-derived, secondary literature is also available.

KEGG pathways involving proteins which contain this domain

This information is based on the mapping of SMART genomic protein database to KEGG orthologous groups. Percentages are related to the number of proteins containing a Bac_DnaA_C domain which could be assigned to a KEGG orthologous group, and not all proteins containing Bac_DnaA_C domains. Please note that proteins can be included in multiple pathways, ie. the numbers below will not add to 100%.

KEGG pathways

Some of these pathways are included in the interactive Pathways Explorer overview maps. Select an overview map and click the button below to highlight them in iPath.

KEGG orthologous groups

Some of these KOs are included in the interactive Pathways Explorer overview maps. Select an overview map and click the button below to highlight them in iPath.

3D structures in PDB containing this domain

Links to other resources describing this domain

InterPro	IPR013159
Pfam	Bac_DnaA_C