Brr6_like_C_C Di-sulfide bridge nucleocytoplasmic transport domain
SMART ACC:	SM001042
Description:	Brr6_like_C_C is the highly conserved C-terminal region of a group of proteins found in fungi. It carries four highly conserved cysteine residues. It is suggested that members of the family interact with each other via di-sulfide bridges to form a complex which is involved in nucleocytoplasmic transport (PUBMED:15882446) .
InterPro ACC:	IPR018767
InterPro abstract:	In Saccharomyces cerevisiae, Brr6 and Brl1 are interacting proteins that localise to the nuclear envelope and regulate lipid homeostasis [ PUBMED:26432634 ]. Mutation studies have implicated the proteins in nuclear pore complex biogenesis and mRNA nuclear export [ PUBMED:11483521 … expand In Saccharomyces cerevisiae, Brr6 and Brl1 are interacting proteins that localise to the nuclear envelope and regulate lipid homeostasis [ PUBMED:26432634 ]. Mutation studies have implicated the proteins in nuclear pore complex biogenesis and mRNA nuclear export [ PUBMED:11483521 ], although it may be that these observed effects are due to defects in maintaining the biophysical properties of the nuclear envelope [ PUBMED:26432634 ]. collapse
GO process:	lipid homeostasis (GO:0055088)
GO component:	nuclear membrane (GO:0031965)
Family alignment:	View the Family alignment or the Alignment consensus sequence
There are 510 Brr6_like_C_C domains in 510 proteins in SMART's NRDB database.

Taxonomic distribution of proteins containing Brr6_like_C_C domains

The tree below includes only several representative species and genera. The complete taxonomic breakdown of all proteins containing Brr6_like_C_C domains can be accessed here. Click the counts or percentage values to display the corresponding proteins.

Predicted cellular role

Cellular role:

Relevant references for this domain

Primary literature for the Brr6_like_C_C domain is listed below. Automatically-derived, secondary literature is also available.

KEGG pathways involving proteins which contain this domain

This information is based on the mapping of SMART genomic protein database to KEGG orthologous groups. Percentages are related to the number of proteins containing a Brr6_like_C_C domain which could be assigned to a KEGG orthologous group, and not all proteins containing Brr6_like_C_C domains. Please note that proteins can be included in multiple pathways, ie. the numbers below will not add to 100%.

KEGG pathways

Some of these pathways are included in the interactive Pathways Explorer overview maps. Select an overview map and click the button below to highlight them in iPath.

KEGG orthologous groups

Some of these KOs are included in the interactive Pathways Explorer overview maps. Select an overview map and click the button below to highlight them in iPath.

Links to other resources describing this domain

Pfam	Brr6_like_C_C
InterPro	IPR018767