 BtzCASC3/Barentsz eIF4AIII binding | |
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| SMART ACC: | SM001044 |
| Description: | This domain is found on CASC3 (cancer susceptibility candidate gene 3 protein) which is also known as Barentsz (Btz). CASC3 is a component of the EJC (exon junction complex) which is a complex that is involved in post-transcriptional regulation of mRNA in metazoa. The complex is formed by the association of four proteins (eIF4AIII, Barentsz, Mago, and Y14), mRNA, and ATP. This domain wraps around eIF4AIII and stacks against the 5' nucleotide (PUBMED:16923391). |
| InterPro ACC: | IPR018545 |
| InterPro abstract: | This domain is found on CASC3 (cancer susceptibility candidate gene 3 protein, also known as MLN51) which is also known as Barentsz (Btz). CASC3 is a component of the EJC (exon junction complex) which is a complex that is involved in post-transcriptional regulation of mRNA in metazoa. The complex is formed by the association of four proteins (eIF4AIII, Barentsz, Mago, and Y14), mRNA, and ATP. … expand |
| GO process: | mRNA processing (GO:0006397) |
| GO component: | exon-exon junction complex (GO:0035145) |
| GO function: | mRNA binding (GO:0003729) |
| Family alignment: | View the Family alignment or the Alignment consensus sequence |
| There are 1 119 Btz domains in 1 117 proteins in SMART's NRDB database. | |
Taxonomic distribution of proteins containing Btz domains
The tree below includes only several representative species and genera. The complete taxonomic breakdown of all proteins containing Btz domains can be accessed here. Click the counts or percentage values to display the corresponding proteins.
Predicted cellular role
| Cellular role: | Transcription |
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Relevant references for this domain
Primary literature for the Btz domain is listed below. Automatically-derived, secondary literature is also available.
KEGG pathways involving proteins which contain this domain
This information is based on the mapping of SMART genomic protein database to KEGG orthologous groups. Percentages are related to the number of proteins containing a Btz domain which could be assigned to a KEGG orthologous group, and not all proteins containing Btz domains. Please note that proteins can be included in multiple pathways, ie. the numbers below will not add to 100%.