 C1_4TFIIH C1-like domain | |
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| SMART ACC: | SM001047 |
| Description: | The carboxyl-terminal region of TFIIH is essential for transcription activity. This regions binds three zinc atoms through two independent domain. The first contains a C4 zinc finger motif, whereas the second is characterised by a CX(2)CX(2-4)FCADCD motif. The solution structure of the second C-terminal domain revealed homology with the regulatory domain of protein kinase C (PUBMED:10882739). |
| InterPro ACC: | IPR004595 |
| InterPro abstract: | The carboxyl-terminal region of TFIIH is essential for transcription activity. This regions binds three zinc atoms through two independent domains. The first contains a C4 zinc finger motif, whereas the second is characterised by a CX(2)CX(2-4)FCADCD motif. The solution structure of the second C-terminal domain revealed homology with the regulatory domain of protein kinase C [ expand |
| GO process: | DNA repair (GO:0006281) |
| GO function: | zinc ion binding (GO:0008270) |
| Family alignment: | View the Family alignment or the Alignment consensus sequence |
| There are 1 283 C1_4 domains in 1 282 proteins in SMART's NRDB database. | |
Taxonomic distribution of proteins containing C1_4 domains
The tree below includes only several representative species and genera. The complete taxonomic breakdown of all proteins containing C1_4 domains can be accessed here. Click the counts or percentage values to display the corresponding proteins.
Predicted cellular role
| Cellular role: | Transcription |
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Relevant references for this domain
Primary literature for the C1_4 domain is listed below. Automatically-derived, secondary literature is also available.
KEGG pathways involving proteins which contain this domain
This information is based on the mapping of SMART genomic protein database to KEGG orthologous groups. Percentages are related to the number of proteins containing a C1_4 domain which could be assigned to a KEGG orthologous group, and not all proteins containing C1_4 domains. Please note that proteins can be included in multiple pathways, ie. the numbers below will not add to 100%.