CADGDystroglycan-type cadherin-like domains. | |
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| SMART ACC: | SM000736 |
| Description: | Cadherin-homologous domains present in metazoan dystroglycans and alpha/epsilon sarcoglycans, yeast Axl2p and in a very large protein from magnetotactic bacteria. Likely to bind calcium ions. |
| InterPro ACC: | IPR006644 |
| InterPro abstract: | In animals, cadherin domain-containing proteins are adhesion molecules that modulate a wide variety of processes including cell polarization and migration but they have also been identified in yeast and magnetotactic bacteria. Crystal structures have revealed that multiple cadherin domains form Ca 2+ -dependent rod-like structures with a conserved Ca 2+ -binding pocket at … expand |
| GO component: | membrane (GO:0016020) |
| Family alignment: | View the Family alignment or the Alignment consensus sequence |
| There are 15 915 CADG domains in 6 264 proteins in SMART's NRDB database. | |
Taxonomic distribution of proteins containing CADG domains
The tree below includes only several representative species and genera. The complete taxonomic breakdown of all proteins containing CADG domains can be accessed here. Click the counts or percentage values to display the corresponding proteins.
Predicted cellular role
| Cellular role: | Signalling |
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| Binding / catalysis: | Likely calcium ions. |
Relevant references for this domain
Primary literature for the CADG domain is listed below. Automatically-derived, secondary literature is also available.
KEGG pathways involving proteins which contain this domain
This information is based on the mapping of SMART genomic protein database to KEGG orthologous groups. Percentages are related to the number of proteins containing a CADG domain which could be assigned to a KEGG orthologous group, and not all proteins containing CADG domains. Please note that proteins can be included in multiple pathways, ie. the numbers below will not add to 100%.
KEGG pathways
KEGG orthologous groups
3D structures in PDB containing this domain
Links to other resources describing this domain
| InterPro | IPR006644 |
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