 CTDSpt5 C-terminal nonapeptide repeat binding Spt4 | |
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| SMART ACC: | SM001104 |
| Description: | The C-terminal domain of the transcription elongation factor protein Spt5 is necessary for binding to Spt4 to form the functional complex that regulates early transcription elongation by RNA polymerase II. The complex may be involved in pre-mRNA processing through its association with mRNA capping enzymes. This CTD domain carries a regular nonapeptide repeat that can be present in up to 18 copies, as in S. pombe (PUBMED:19460865). The repeat has a characteristic TPA motif. |
| InterPro ACC: | IPR024945 |
| InterPro abstract: | The C-terminal domain of the transcription elongation factor protein Spt5 is necessary for binding to Spt4 to form the functional complex that regulates early transcription elongation by RNA polymerase II. The complex may be involved in pre-mRNA processing through its association with mRNA capping enzymes. This CTD domain carries a regular nonapeptide repeat that can be present in up to 18 copies … expand |
| GO function: | protein binding (GO:0005515) |
| Family alignment: | View the Family alignment or the Alignment consensus sequence |
| There are 1 111 CTD domains in 1 071 proteins in SMART's NRDB database. | |
Taxonomic distribution of proteins containing CTD domains
The tree below includes only several representative species and genera. The complete taxonomic breakdown of all proteins containing CTD domains can be accessed here. Click the counts or percentage values to display the corresponding proteins.
Predicted cellular role
| Cellular role: | Transcription |
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Relevant references for this domain
Primary literature for the CTD domain is listed below. Automatically-derived, secondary literature is also available.
KEGG pathways involving proteins which contain this domain
This information is based on the mapping of SMART genomic protein database to KEGG orthologous groups. Percentages are related to the number of proteins containing a CTD domain which could be assigned to a KEGG orthologous group, and not all proteins containing CTD domains. Please note that proteins can be included in multiple pathways, ie. the numbers below will not add to 100%.