 CaMBDCalmodulin binding domain | |
|---|---|
| SMART ACC: | SM001053 |
| Description: | Small-conductance Ca2+-activated K+ channels (SK channels) are independent of voltage and gated solely by intracellular Ca2+. These membrane channels are heteromeric complexes that comprise pore-forming alpha-subunits and the Ca2+-binding protein calmodulin (CaM) (PUBMED:11323678). CaM binds to the SK channel through this the CaM-binding domain (CaMBD), which is located in an intracellular region of the alpha-subunit immediately carboxy-terminal to the pore. Channel opening is triggered when Ca2+ binds the EF hands in the N-lobe of CaM. The structure of this domain complexed with CaM is known (PUBMED:11323678). This domain forms an elongated dimer with a CaM molecule bound at each end; each CaM wraps around three alpha-helices, two from one CaMBD subunit and one from the other. |
| InterPro ACC: | IPR004178 |
| InterPro abstract: | Small-conductance Ca2+-activated K+ channels (SK channels) are independent of voltage and gated solely by intracellular Ca2+. These membrane channels are heteromeric complexes that comprise pore-forming alpha-subunits and the Ca2+-binding protein calmodulin (CaM) [ PUBMED:11323678 ]. CaM binds to the SK channel through … expand |
| GO process: | potassium ion transport (GO:0006813) |
| GO component: | membrane (GO:0016020) |
| GO function: | calcium-activated potassium channel activity (GO:0015269), calmodulin binding (GO:0005516) |
| Family alignment: | View the Family alignment or the Alignment consensus sequence |
| There are 1 789 CaMBD domains in 1 786 proteins in SMART's NRDB database. | |
Taxonomic distribution of proteins containing CaMBD domains
The tree below includes only several representative species and genera. The complete taxonomic breakdown of all proteins containing CaMBD domains can be accessed here. Click the counts or percentage values to display the corresponding proteins.
Relevant references for this domain
Primary literature for the CaMBD domain is listed below. Automatically-derived, secondary literature is also available.
KEGG pathways involving proteins which contain this domain
This information is based on the mapping of SMART genomic protein database to KEGG orthologous groups. Percentages are related to the number of proteins containing a CaMBD domain which could be assigned to a KEGG orthologous group, and not all proteins containing CaMBD domains. Please note that proteins can be included in multiple pathways, ie. the numbers below will not add to 100%.