 Cache_2 | |
|---|---|
| SMART ACC: | SM001049 |
| Description: | Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins, including the animal dihydropyridine-sensitive voltage-gated Ca2+ channel; alpha-2delta subunit, and various bacterial chemotaxis receptors. The name Cache comes from CAlcium channels and CHEmotaxis receptors. This domain consists of an N-terminal part with three predicted strands and an alpha-helix, and a C-terminal part with a strand dyad followed by a relatively unstructured region. The N-terminal portion of the (unpermuted) Cache domain contains three predicted strands that could form a sheet analogous to that present in the core of the PAS domain structure. Cache domains are particularly widespread in bacteria, with Vibrio cholerae. The animal calcium channel alpha-2delta subunits might have acquired a part of their extracellular domains from a bacterial source (PUBMED:11084361). The Cache domain appears to have arisen from the GAF-PAS fold despite their divergent functions (PUBMED:11292341). |
| InterPro ACC: | IPR033480 |
| InterPro abstract: | Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins, including the animal dihydropyridine-sensitive voltage-gated Ca2 channel alpha-2delta subunit, and various bacterial chemotaxis receptors. The name Cache comes from CAlcium channels and CHEmotaxis receptors. This entry represents the single Cache domain 2 (sCache_2) … expand |
| Family alignment: | View the Family alignment or the Alignment consensus sequence |
| There are 15 048 Cache_2 domains in 13 761 proteins in SMART's NRDB database. | |
Taxonomic distribution of proteins containing Cache_2 domains
The tree below includes only several representative species and genera. The complete taxonomic breakdown of all proteins containing Cache_2 domains can be accessed here. Click the counts or percentage values to display the corresponding proteins.
Relevant references for this domain
Primary literature for the Cache_2 domain is listed below. Automatically-derived, secondary literature is also available.
KEGG pathways involving proteins which contain this domain
This information is based on the mapping of SMART genomic protein database to KEGG orthologous groups. Percentages are related to the number of proteins containing a Cache_2 domain which could be assigned to a KEGG orthologous group, and not all proteins containing Cache_2 domains. Please note that proteins can be included in multiple pathways, ie. the numbers below will not add to 100%.