 Cir_NN-terminal domain of CBF1 interacting co-repressor CIR | |
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| SMART ACC: | SM001083 |
| Description: | This is a 45 residue conserved region at the N-terminal end of a family of proteins referred to as CIRs (CBF1-interacting co-repressors). CBF1 (centromere-binding factor 1) acts as a transcription factor that causes repression by binding specifically to GTGGGAA motifs in responsive promoters, and it requires CIR as a co-repressor. CIR binds to histone deacetylase and to SAP30 and serves as a linker between CBF1 and the histone deacetylase complex (PUBMED:9874765). |
| InterPro ACC: | IPR019339 |
| InterPro abstract: | This entry represents a 45 residue conserved domain found at the N-terminal end CIR protein (CBF1-interacting co-repressor, also known as corepressor interacting with RBPJ 1). This domain can be found in the fungal CWC25 family members and mammlian LENG1 (leukocyte receptor cluster member 1) protein. CBF1 (centromere-binding factor 1) acts as a transcription factor that causes repression … expand |
| Family alignment: | View the Family alignment or the Alignment consensus sequence |
| There are 2 628 Cir_N domains in 2 626 proteins in SMART's NRDB database. | |
Taxonomic distribution of proteins containing Cir_N domains
The tree below includes only several representative species and genera. The complete taxonomic breakdown of all proteins containing Cir_N domains can be accessed here. Click the counts or percentage values to display the corresponding proteins.
Predicted cellular role
| Cellular role: | Transcription |
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Relevant references for this domain
Primary literature for the Cir_N domain is listed below. Automatically-derived, secondary literature is also available.
KEGG pathways involving proteins which contain this domain
This information is based on the mapping of SMART genomic protein database to KEGG orthologous groups. Percentages are related to the number of proteins containing a Cir_N domain which could be assigned to a KEGG orthologous group, and not all proteins containing Cir_N domains. Please note that proteins can be included in multiple pathways, ie. the numbers below will not add to 100%.