This is a ~120-amino acid protein-protein interaction module that binds DMAP1 (DNA methyltransferase-associated protein 1), a transcriptional co-repressor. It is found at the N terminus of DNMT1 (DNA methyltransferase 1) [ PUBMED:10888872 ] and animal disco-interacting protein 2 (DIP-2), a protein that maintains morphology … expand

This is a ~120-amino acid protein-protein interaction module that binds DMAP1 (DNA methyltransferase-associated protein 1), a transcriptional co-repressor. It is found at the N terminus of DNMT1 (DNA methyltransferase 1) [ PUBMED:10888872 ] and animal disco-interacting protein 2 (DIP-2), a protein that maintains morphology of mature neurons [ PUBMED:27908785 PUBMED:30396999 ]. This domain is also found in N-acetylglucosamine-1-phosphotransferase subunits alpha/beta (GNPTA) and gamma (GNPTG) from animals, which are members of a complex that catalyses the initial step in the formation of the mannose 6-phopsphate targeting signal on newly synthesized lysosomal acid hydrolases. The DMAP1-binding domain mediates the selective binding GlcNAc-1-phosphotranferase to acid hydrolases [ PUBMED:23733939 PUBMED:25505245 ].

The DMAP1-binding domain is predicted to adopt a long helix-turn-helix structure that is rich in leucine residues [ PUBMED:8940105 ].