DNA_mis_repair DNA mismatch repair protein, C-terminal domain
SMART ACC:	SM001340
Description:	DNA mismatch repair protein, C-terminal domain.
InterPro ACC:	IPR013507
InterPro abstract:	This domain is found in MutL and homologues and is characterised by a ribosomal protein S5 domain 2-like fold [ PUBMED:26249686 ]. The dimeric MutL protein has a key function in communicating mismatch recognition by MutS to downstream repair processes. Mismatch repair contributes to the overall fidelity of … expand This domain is found in MutL and homologues and is characterised by a ribosomal protein S5 domain 2-like fold [ PUBMED:26249686 ]. The dimeric MutL protein has a key function in communicating mismatch recognition by MutS to downstream repair processes. Mismatch repair contributes to the overall fidelity of DNA replication by targeting mispaired bases that arise through replication errors during homologous recombination and as a result of DNA damage. It involves the correction of mismatched base pairs that have been missed by the proofreading element of the DNA polymerase complex [ PUBMED:14527292 ]. collapse
GO process:	mismatch repair (GO:0006298)
GO function:	ATP binding (GO:0005524), mismatched DNA binding (GO:0030983)
Family alignment:	View the Family alignment or the Alignment consensus sequence
There are 22 878 DNA_mis_repair domains in 22 875 proteins in SMART's NRDB database.

Taxonomic distribution of proteins containing DNA_mis_repair domains

The tree below includes only several representative species and genera. The complete taxonomic breakdown of all proteins containing DNA_mis_repair domains can be accessed here. Click the counts or percentage values to display the corresponding proteins.

Relevant references for this domain

Primary literature for the DNA_mis_repair domain is listed below. Automatically-derived, secondary literature is also available.

KEGG pathways involving proteins which contain this domain

This information is based on the mapping of SMART genomic protein database to KEGG orthologous groups. Percentages are related to the number of proteins containing a DNA_mis_repair domain which could be assigned to a KEGG orthologous group, and not all proteins containing DNA_mis_repair domains. Please note that proteins can be included in multiple pathways, ie. the numbers below will not add to 100%.

KEGG pathways

Some of these pathways are included in the interactive Pathways Explorer overview maps. Select an overview map and click the button below to highlight them in iPath.

KEGG orthologous groups

Some of these KOs are included in the interactive Pathways Explorer overview maps. Select an overview map and click the button below to highlight them in iPath.

3D structures in PDB containing this domain

Links to other resources describing this domain

InterPro	IPR013507
Pfam	DNA_mis_repair