 DPTranscription factor DP | |
|---|---|
| SMART ACC: | SM001138 |
| Description: | DP forms a heterodimer with E2F and regulates genes involved in cell cycle progression. The transcriptional activity of E2F is inhibited by the retinoblastoma protein which binds to the E2F-DP heterodimer [(PUBMED:16360038)] and negatively regulates the G1-S transition. |
| InterPro ACC: | IPR014889 |
| InterPro abstract: | The transcription factor DP (dimerization partner) forms a heterodimer with E2F and regulates genes involved in cell cycle progression. The transcriptional activity of E2F is inhibited by the retinoblastoma protein which binds to the E2F-DP heterodimer [ PUBMED:16360038 ] and negatively regulates the G1-S transition. … expand |
| Family alignment: | View the Family alignment or the Alignment consensus sequence |
| There are 1 503 DP domains in 1 502 proteins in SMART's NRDB database. | |
Taxonomic distribution of proteins containing DP domains
The tree below includes only several representative species and genera. The complete taxonomic breakdown of all proteins containing DP domains can be accessed here. Click the counts or percentage values to display the corresponding proteins.
Predicted cellular role
| Cellular role: | Transcription |
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Relevant references for this domain
Primary literature for the DP domain is listed below. Automatically-derived, secondary literature is also available.
KEGG pathways involving proteins which contain this domain
This information is based on the mapping of SMART genomic protein database to KEGG orthologous groups. Percentages are related to the number of proteins containing a DP domain which could be assigned to a KEGG orthologous group, and not all proteins containing DP domains. Please note that proteins can be included in multiple pathways, ie. the numbers below will not add to 100%.