 DSS1_SEM1 | |
|---|---|
| SMART ACC: | SM001385 |
| Description: | This family contains the breast cancer tumour suppressor BRCA2-interacting protein DSS1 and its homologue SEM1, both of which are short acidic proteins. DSS1 has been shown to be a conserved component of the Rae1 mediated mRNA export pathway in Schizosaccharomyces pombe (PMID:15990877). |
| InterPro ACC: | IPR007834 |
| InterPro abstract: | This family includes yeast Sem1 and its mammalian homologue, DSS1. Sem1/DSS1 (also known as rpn15) is a component of lid subcomplex of 26S proteasome regulatory subunit [ PUBMED:23643786 PUBMED:24412063 PUBMED:15117943 … expand |
| GO process: | proteasome assembly (GO:0043248), mRNA export from nucleus (GO:0006406) |
| GO component: | proteasome regulatory particle, lid subcomplex (GO:0008541) |
| Family alignment: | View the Family alignment or the Alignment consensus sequence |
| There are 1 265 DSS1_SEM1 domains in 1 265 proteins in SMART's NRDB database. | |
Taxonomic distribution of proteins containing DSS1_SEM1 domains
The tree below includes only several representative species and genera. The complete taxonomic breakdown of all proteins containing DSS1_SEM1 domains can be accessed here. Click the counts or percentage values to display the corresponding proteins.
Predicted cellular role
| Cellular role: |
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Relevant references for this domain
Primary literature for the DSS1_SEM1 domain is listed below. Automatically-derived, secondary literature is also available.
KEGG pathways involving proteins which contain this domain
This information is based on the mapping of SMART genomic protein database to KEGG orthologous groups. Percentages are related to the number of proteins containing a DSS1_SEM1 domain which could be assigned to a KEGG orthologous group, and not all proteins containing DSS1_SEM1 domains. Please note that proteins can be included in multiple pathways, ie. the numbers below will not add to 100%.