 DUF862PPPDE putative peptidase domain | |
|---|---|
| SMART ACC: | SM001179 |
| Description: | The PPPDE superfamily (after Permuted Papain fold Peptidases of DsRNA viruses and Eukaryotes), consists of predicted thiol peptidases with a circularly permuted papain-like fold. The inference of the likely DUB function of the PPPDE superfamily proteins is based on the fusions of the catalytic domain to Ub-binding PUG (PUB)/UBA domains and a novel alpha-helical Ub-associated domain (the PUL domain, after PLAP, Ufd3p and Lub1p) (PUBMED:15483401). |
| InterPro ACC: | IPR008580 |
| InterPro abstract: | The PPPDE superfamily (after Permuted Papain fold Peptidases of DsRNA viruses and Eukaryotes), consists of thiol peptidases with a circularly permuted papain-like fold. They contain a PPPDE domain which is a cysteine isopeptidase that exhibits a deSUMOylase activity in PPPDE2 (DeSI-1) and a deubiquinating activity in PPPDE1 (DeSI-2) and is described as a mixed α/β-fold composed of six β-strands … expand |
| GO function: | peptidase activity (GO:0008233) |
| Family alignment: | View the Family alignment or the Alignment consensus sequence |
| There are 4 571 DUF862 domains in 4 569 proteins in SMART's NRDB database. | |
Taxonomic distribution of proteins containing DUF862 domains
The tree below includes only several representative species and genera. The complete taxonomic breakdown of all proteins containing DUF862 domains can be accessed here. Click the counts or percentage values to display the corresponding proteins.
Relevant references for this domain
Primary literature for the DUF862 domain is listed below. Automatically-derived, secondary literature is also available.
KEGG pathways involving proteins which contain this domain
This information is based on the mapping of SMART genomic protein database to KEGG orthologous groups. Percentages are related to the number of proteins containing a DUF862 domain which could be assigned to a KEGG orthologous group, and not all proteins containing DUF862 domains. Please note that proteins can be included in multiple pathways, ie. the numbers below will not add to 100%.