ELFV_dehydrog Glutamate/Leucine/Phenylalanine/Valine dehydrogenase
SMART ACC:	SM000839
Description:	Glutamate, leucine, phenylalanine and valine dehydrogenases are structurally and functionally related. They contain a Gly-rich region containing a conserved Lys residue, which has been implicated in the catalytic activity, in each case a reversible oxidative deamination reaction.
InterPro ACC:	IPR006096
InterPro abstract:	Glutamate, leucine, phenylalanine, valine and tryptophan dehydrogenases are structurally and functionally related. They contain a Gly-rich region containing a conserved Lys residue, which has been implicated in the catalytic activity, in each case a reversible oxidative deamination reaction. Glutamate dehydrogenases ( EC:1.4.1.2 … expand Glutamate, leucine, phenylalanine, valine and tryptophan dehydrogenases are structurally and functionally related. They contain a Gly-rich region containing a conserved Lys residue, which has been implicated in the catalytic activity, in each case a reversible oxidative deamination reaction. Glutamate dehydrogenases ( EC:1.4.1.2 EC:1.4.1.3 and EC:1.4.1.4 ) (GluDH) are enzymes that catalyse the NAD-and/or NADP-dependent reversible deamination of L-glutamate into alpha-ketoglutarate [ PUBMED:1358610 PUBMED:8315654 ]. GluDH isozymes are generally involved with either ammonia assimilation or glutamate catabolism. Two separate enzymes are present in yeasts: the NADP-dependent enzyme, which catalyses the amination of alpha-ketoglutarate to L-glutamate; and the NAD-dependent enzyme, which catalyses the reverse reaction [ PUBMED:2989290 ] -this form links the L-amino acids with the Krebs cycle, which provides a major pathway for metabolic interconversion of alpha-amino acids and alpha-keto acids [ PUBMED:3368458 ]. In rice, glutamate dehydrogenase 3 is mitochondrial. Leucine dehydrogenase ( EC:1.4.1.9 ) (LeuDH) is a NAD-dependent enzyme that catalyses the reversible deamination of leucine and several other aliphatic amino acids to their keto analogues [ PUBMED:3069133 ]. Each subunit of this octameric enzyme from Bacillus sphaericus contains 364 amino acids and folds into two domains, separated by a deep cleft. The nicotinamide ring of the NAD+ cofactor binds deep in this cleft, which is thought to close during the hydride transfer step of the catalytic cycle. Phenylalanine dehydrogenase ( EC:1.4.1.20 ) (PheDH) is na NAD-dependent enzyme that catalyses the reversible deamidation of L-phenylalanine into phenyl-pyruvate [ PUBMED:1880121 ]. Valine dehydrogenase ( EC:1.4.1.8 ) (ValDH) is an NADP-dependent enzyme that catalyses the reversible deamidation of L-valine into 3-methyl-2-oxobutanoate [ PUBMED:8320231 ]. L-tryptophan dehydrogenase catalyses the reversible oxidative deamination of L-tryptophan to indole-3-pyruvate in the presence of NAD+ [ PUBMED:24835098 PUBMED:27815281 ]. This entry represents the C-terminal domain of these proteins. collapse
GO process:	amino acid metabolic process (GO:0006520)
GO function:	oxidoreductase activity (GO:0016491)
Family alignment:	View the Family alignment or the Alignment consensus sequence
There are 30 530 ELFV_dehydrog domains in 30 511 proteins in SMART's NRDB database.

Taxonomic distribution of proteins containing ELFV_dehydrog domains

The tree below includes only several representative species and genera. The complete taxonomic breakdown of all proteins containing ELFV_dehydrog domains can be accessed here. Click the counts or percentage values to display the corresponding proteins.

Predicted cellular role

Cellular role:	Metabolic

Relevant references for this domain

Primary literature for the ELFV_dehydrog domain is listed below. Automatically-derived, secondary literature is also available.

KEGG pathways involving proteins which contain this domain

This information is based on the mapping of SMART genomic protein database to KEGG orthologous groups. Percentages are related to the number of proteins containing a ELFV_dehydrog domain which could be assigned to a KEGG orthologous group, and not all proteins containing ELFV_dehydrog domains. Please note that proteins can be included in multiple pathways, ie. the numbers below will not add to 100%.

KEGG pathways

Some of these pathways are included in the interactive Pathways Explorer overview maps. Select an overview map and click the button below to highlight them in iPath.

KEGG orthologous groups

Some of these KOs are included in the interactive Pathways Explorer overview maps. Select an overview map and click the button below to highlight them in iPath.

3D structures in PDB containing this domain

Links to other resources describing this domain

Pfam	ELFV_dehydrog
InterPro	IPR006096