 ERCC4ERCC4 domain | |
|---|---|
| SMART ACC: | SM000891 |
| Description: | This entry represents a structural motif found in several DNA repair nucleases, such as Rad1/Mus81/XPF endonucleases, and in ATP-dependent helicases. The XPF/Rad1/Mus81-dependent nuclease family specifically cleaves branched structures generated during DNA repair, replication, and recombination, and is essential for maintaining genome stability. The nuclease domain architecture exhibits remarkable similarity to those of restriction endonucleases. |
| InterPro ACC: | IPR006166 |
| InterPro abstract: | This entry represents a structural domain found in several DNA repair nucleases, such as Rad1, XPF and crossover junction endonucleases EME1 and Mus81 [ PUBMED:12679022 PUBMED:14527419 ]. The XPF/Rad1/Mus81-dependent nuclease family specifically … expand |
| GO function: | nuclease activity (GO:0004518), DNA binding (GO:0003677) |
| Family alignment: | View the Family alignment or the Alignment consensus sequence |
| There are 6 162 ERCC4 domains in 6 145 proteins in SMART's NRDB database. | |
Taxonomic distribution of proteins containing ERCC4 domains
The tree below includes only several representative species and genera. The complete taxonomic breakdown of all proteins containing ERCC4 domains can be accessed here. Click the counts or percentage values to display the corresponding proteins.
Predicted cellular role
| Cellular role: | Transport |
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Relevant references for this domain
Primary literature for the ERCC4 domain is listed below. Automatically-derived, secondary literature is also available.
KEGG pathways involving proteins which contain this domain
This information is based on the mapping of SMART genomic protein database to KEGG orthologous groups. Percentages are related to the number of proteins containing a ERCC4 domain which could be assigned to a KEGG orthologous group, and not all proteins containing ERCC4 domains. Please note that proteins can be included in multiple pathways, ie. the numbers below will not add to 100%.