 FTCD_NFormiminotransferase domain, N-terminal subdomain | |
|---|---|
| SMART ACC: | SM001222 |
| Description: | The formiminotransferase (FT) domain of formiminotransferase- cyclodeaminase (FTCD) forms a homodimer, and each protomer comprises two subdomains. The N-terminal subdomain is made up of a six-stranded mixed beta-pleated sheet and five alpha helices, which are arranged on the external surface of the beta sheet. This, in turn, faces the beta-sheet of the C-terminal subdomain to form a double beta-sheet layer. The two subdomains are separated by a short linker sequence, which is not thought to be any more flexible than the remainder of the molecule. The substrate is predicted to form a number of contacts with residues found in both the N-terminal and C-terminal subdomains (PUBMED:10673422). |
| InterPro ACC: | IPR012886 |
| InterPro abstract: | The formiminotransferase (FT) domain of formiminotransferase-cyclodeaminase (FTCD) forms a homodimer, with each protomer being comprised of two subdomains. The formiminotransferase domain has an N-terminal subdomain that is made up of a six-stranded mixed β-pleated sheet and five α-helices, which are arranged on the external surface of the β-sheet. This, in turn, faces the β-sheet of the C-terminal … expand |
| GO function: | folic acid binding (GO:0005542), transferase activity (GO:0016740) |
| Family alignment: | View the Family alignment or the Alignment consensus sequence |
| There are 3 086 FTCD_N domains in 3 083 proteins in SMART's NRDB database. | |
Taxonomic distribution of proteins containing FTCD_N domains
The tree below includes only several representative species and genera. The complete taxonomic breakdown of all proteins containing FTCD_N domains can be accessed here. Click the counts or percentage values to display the corresponding proteins.
Relevant references for this domain
Primary literature for the FTCD_N domain is listed below. Automatically-derived, secondary literature is also available.
KEGG pathways involving proteins which contain this domain
This information is based on the mapping of SMART genomic protein database to KEGG orthologous groups. Percentages are related to the number of proteins containing a FTCD_N domain which could be assigned to a KEGG orthologous group, and not all proteins containing FTCD_N domains. Please note that proteins can be included in multiple pathways, ie. the numbers below will not add to 100%.