 FerI | |
|---|---|
| SMART ACC: | SM001202 |
| Description: | This domain is present in proteins of the Ferlin family. It is often located between two C2 domains PMID:15112237 . |
| InterPro ACC: | IPR012968 |
| InterPro abstract: | The ferlin gene family are characterised by multiple tandem C2 domains and a C-terminal transmembrane domain. They are found in a wide range of species and their function remains unknown, however, mutations in its two most well-characterised members, dysferlin and otoferlin, have been implicated in human disease [ PUBMED:20667140 … expand |
| Family alignment: | View the Family alignment or the Alignment consensus sequence |
| There are 3 316 FerI domains in 3 311 proteins in SMART's NRDB database. | |
Taxonomic distribution of proteins containing FerI domains
The tree below includes only several representative species and genera. The complete taxonomic breakdown of all proteins containing FerI domains can be accessed here. Click the counts or percentage values to display the corresponding proteins.
Relevant references for this domain
Primary literature for the FerI domain is listed below. Automatically-derived, secondary literature is also available.
KEGG pathways involving proteins which contain this domain
This information is based on the mapping of SMART genomic protein database to KEGG orthologous groups. Percentages are related to the number of proteins containing a FerI domain which could be assigned to a KEGG orthologous group, and not all proteins containing FerI domains. Please note that proteins can be included in multiple pathways, ie. the numbers below will not add to 100%.