 FolBDihydroneopterin aldolase | |
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| SMART ACC: | SM000905 |
| Description: | Dihydroneopterin aldolase catalyses the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin in the biosynthetic pathway of tetrahydrofolate. In the opportunistic pathogen Pneumocystis carinii, dihydroneopterin aldolase function is expressed as the N-terminal portion of the multifunctional folic acid synthesis protein (Fas). This region encompasses two domains, FasA and FasB, which are 27% amino acid identical. FasA and FasB also share significant amino acid sequence similarity with bacterial dihydroneopterin aldolases. This region consists of two tandem sequences each homologous to folB and which form tetramers (PUBMED:9709001). |
| InterPro ACC: | IPR006157 |
| InterPro abstract: | Dihydroneopterin aldolase (DHNA or folB) catalyses the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin in the biosynthetic pathway of tetrahydrofolate [ PUBMED:12039964 ]. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids, as well as formyl-tRNA. … expand |
| GO process: | folic acid-containing compound metabolic process (GO:0006760) |
| GO function: | dihydroneopterin aldolase activity (GO:0004150) |
| Family alignment: | View the Family alignment or the Alignment consensus sequence |
| There are 18 261 FolB domains in 17 999 proteins in SMART's NRDB database. | |
Taxonomic distribution of proteins containing FolB domains
The tree below includes only several representative species and genera. The complete taxonomic breakdown of all proteins containing FolB domains can be accessed here. Click the counts or percentage values to display the corresponding proteins.
Predicted cellular role
| Cellular role: | Metabolic |
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Relevant references for this domain
Primary literature for the FolB domain is listed below. Automatically-derived, secondary literature is also available.
KEGG pathways involving proteins which contain this domain
This information is based on the mapping of SMART genomic protein database to KEGG orthologous groups. Percentages are related to the number of proteins containing a FolB domain which could be assigned to a KEGG orthologous group, and not all proteins containing FolB domains. Please note that proteins can be included in multiple pathways, ie. the numbers below will not add to 100%.