GAL4 GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain
SMART ACC:	SM000066
Description:	Gal4 is a positive regulator for the gene expression of the galactose- induced genes of S. cerevisiae. Is present only in fungi.
InterPro ACC:	IPR001138
InterPro abstract:	The N-terminal region of a number of fungal transcriptional regulatory proteins contains a Cys-rich motif that is involved in zinc-dependent binding of DNA. The region forms a binuclear Zn cluster, in which two Zn atoms are bound by six Cys residues [ PUBMED:2107541 PUBMED:1557122 … expand The N-terminal region of a number of fungal transcriptional regulatory proteins contains a Cys-rich motif that is involved in zinc-dependent binding of DNA. The region forms a binuclear Zn cluster, in which two Zn atoms are bound by six Cys residues [ PUBMED:2107541 PUBMED:1557122 ]. A wide range of proteins are known to contain this domain. These include the proteins involved in arginine, proline, pyrimidine, quinate, maltose and galactose metabolism, amide and GABA catabolism, leucine biosynthesis, amongst others. The structure of Zn2Cys6 DNA-binding domain from different proteins has been determined in free and DNA bound state revealing details of the molecular basis of DNA recognition [ PUBMED:9303004 PUBMED:11566132 PUBMED:7958913 ]. collapse
GO process:	regulation of DNA-templated transcription (GO:0006355)
GO function:	DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981), zinc ion binding (GO:0008270)
Family alignment:	View the Family alignment or the Alignment consensus sequence
There are 99 989 GAL4 domains in 98 576 proteins in SMART's NRDB database.

Taxonomic distribution of proteins containing GAL4 domains

The tree below includes only several representative species and genera. The complete taxonomic breakdown of all proteins containing GAL4 domains can be accessed here. Click the counts or percentage values to display the corresponding proteins.

Relevant references for this domain

Primary literature for the GAL4 domain is listed below. Automatically-derived, secondary literature is also available.

KEGG pathways involving proteins which contain this domain

This information is based on the mapping of SMART genomic protein database to KEGG orthologous groups. Percentages are related to the number of proteins containing a GAL4 domain which could be assigned to a KEGG orthologous group, and not all proteins containing GAL4 domains. Please note that proteins can be included in multiple pathways, ie. the numbers below will not add to 100%.

KEGG pathways

Some of these pathways are included in the interactive Pathways Explorer overview maps. Select an overview map and click the button below to highlight them in iPath.

KEGG orthologous groups

Some of these KOs are included in the interactive Pathways Explorer overview maps. Select an overview map and click the button below to highlight them in iPath.

3D structures in PDB containing this domain

Links to other resources describing this domain

InterPro	IPR001138
PROSITE	GAL4_DOMAIN
Pfam	Zn_clus