 GARS_CPhosphoribosylglycinamide synthetase, C domain | |
|---|---|
| SMART ACC: | SM001210 |
| Description: | Phosphoribosylglycinamide synthetase catalyses the second step in the de novo biosynthesis of purine. The reaction catalysed by Phosphoribosylglycinamide synthetase is the ATP- dependent addition of 5-phosphoribosylamine to glycine to form 5'phosphoribosylglycinamide. This domain is related to the C-terminal domain of biotin carboxylase/carbamoyl phosphate synthetase (Pfam PF02787). |
| InterPro ACC: | IPR020560 |
| InterPro abstract: | Phosphoribosylglycinamide synthetase ( EC:6.3.4.13 ) (GARS) (phosphoribosylamine glycine ligase) [ PUBMED:2687276 ] catalyses the second step in the de novo biosynthesis of purine. The reaction catalysed by phosphoribosylglycinamide synthetase … expand |
| GO process: | purine nucleobase biosynthetic process (GO:0009113) |
| GO function: | phosphoribosylamine-glycine ligase activity (GO:0004637) |
| Family alignment: | View the Family alignment or the Alignment consensus sequence |
| There are 23 116 GARS_C domains in 23 108 proteins in SMART's NRDB database. | |
Taxonomic distribution of proteins containing GARS_C domains
The tree below includes only several representative species and genera. The complete taxonomic breakdown of all proteins containing GARS_C domains can be accessed here. Click the counts or percentage values to display the corresponding proteins.
Relevant references for this domain
Primary literature for the GARS_C domain is listed below. Automatically-derived, secondary literature is also available.
KEGG pathways involving proteins which contain this domain
This information is based on the mapping of SMART genomic protein database to KEGG orthologous groups. Percentages are related to the number of proteins containing a GARS_C domain which could be assigned to a KEGG orthologous group, and not all proteins containing GARS_C domains. Please note that proteins can be included in multiple pathways, ie. the numbers below will not add to 100%.