 GDNFGDNF/GAS1 domain | |
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| SMART ACC: | SM000907 |
| Description: | This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons (PUBMED:16551639), (PUBMED:9192899). GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity (PUBMED:9192898). |
| InterPro ACC: | IPR016017 |
| InterPro abstract: | This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons [ PUBMED:16551639 PUBMED:9192899 ]. GDNF … expand |
| Family alignment: | View the Family alignment or the Alignment consensus sequence |
| There are 7 226 GDNF domains in 2 899 proteins in SMART's NRDB database. | |
Taxonomic distribution of proteins containing GDNF domains
The tree below includes only several representative species and genera. The complete taxonomic breakdown of all proteins containing GDNF domains can be accessed here. Click the counts or percentage values to display the corresponding proteins.
Predicted cellular role
| Cellular role: | Signalling |
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Relevant references for this domain
Primary literature for the GDNF domain is listed below. Automatically-derived, secondary literature is also available.
KEGG pathways involving proteins which contain this domain
This information is based on the mapping of SMART genomic protein database to KEGG orthologous groups. Percentages are related to the number of proteins containing a GDNF domain which could be assigned to a KEGG orthologous group, and not all proteins containing GDNF domains. Please note that proteins can be included in multiple pathways, ie. the numbers below will not add to 100%.