H4 Histone H4
SMART ACC:	SM000417
Description:	-
InterPro ACC:	IPR001951
InterPro abstract:	Histone H4 is one of the five histones, along with H1/H5, H2A, H2B and H3. Two copies of each of the H2A, H2B, H3, and H4 histones ensemble to form the core of the nucleosome [ PUBMED:16472024 ]. The nucleosome forms octameric structure that wraps DNA in a left-handed manner. H3 is a highly conserved protein of 135 amino … expand Histone H4 is one of the five histones, along with H1/H5, H2A, H2B and H3. Two copies of each of the H2A, H2B, H3, and H4 histones ensemble to form the core of the nucleosome [ PUBMED:16472024 ]. The nucleosome forms octameric structure that wraps DNA in a left-handed manner. H3 is a highly conserved protein of 135 amino acid residues [ PUBMED:8121801 PUBMED:2041803 ]. Histones can undergo several different types of post-translational modifications that affect transcription, DNA repair, DNA replication and chromosomal stability. The sequence of histone H4 has remained almost invariant in more then 2 billion years of evolution [ PUBMED:8121801 PUBMED:6808351 PUBMED:3340182 ]. collapse
GO function:	DNA binding (GO:0003677), structural constituent of chromatin (GO:0030527)
Family alignment:	View the Family alignment or the Alignment consensus sequence
There are 2 776 H4 domains in 2 524 proteins in SMART's NRDB database.

Taxonomic distribution of proteins containing H4 domains

The tree below includes only several representative species and genera. The complete taxonomic breakdown of all proteins containing H4 domains can be accessed here. Click the counts or percentage values to display the corresponding proteins.

Relevant references for this domain

Primary literature for the H4 domain is listed below. Automatically-derived, secondary literature is also available.

KEGG pathways involving proteins which contain this domain

This information is based on the mapping of SMART genomic protein database to KEGG orthologous groups. Percentages are related to the number of proteins containing a H4 domain which could be assigned to a KEGG orthologous group, and not all proteins containing H4 domains. Please note that proteins can be included in multiple pathways, ie. the numbers below will not add to 100%.

KEGG pathways

Some of these pathways are included in the interactive Pathways Explorer overview maps. Select an overview map and click the button below to highlight them in iPath.

KEGG orthologous groups

Some of these KOs are included in the interactive Pathways Explorer overview maps. Select an overview map and click the button below to highlight them in iPath.

3D structures in PDB containing this domain

Links to other resources describing this domain

Pfam	histone
InterPro	IPR001951
PROSITE	HISTONE_H4